(±)-Gancochlearols J - N, renoprotective meroterpenoids from Ganoderma cochlear.
TL;DR: In this paper, five meroterpenoid enantiomers, (±)-gancochlearols J−−−N (1−5), were isolated from the fruiting bodies of Ganoderma cochlear.
About: This article is published in Bioorganic Chemistry.The article was published on 2021-04-26. It has received 8 citations till now.
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TL;DR: Ganoderma mushrooms are not only traditional Chinese medicine, but also dietary supplements and functional foods worldwide as mentioned in this paper, and Ganoderma is used as new anti-renal fibrosis and improve insulin resistance functional food and medicine.
7 citations
TL;DR: In this paper , five new meroterpenoids were isolated from the fruiting bodies of Ganoderma lucidum and the structures including their absolute configurations were characterized by using spectroscopic and computational methods.
3 citations
TL;DR: Sesquiterpene quinone/quinols (SQs) are characterized by a C15-sesquiterpenoid unit incorporating a C6-benzoquinone/quinol moiety as mentioned in this paper .
1 citations
TL;DR: Zhao et al. as mentioned in this paper identified potential neurotrophic chemists related to the memory impairment usage to slow down pathogenetic process and restore neural circuits for Alzheimer's disease, which is a chromic progressive neurodegenerative disorder associated with loss of memory and cognition.
1 citations
TL;DR: The results of biochemical studies using a palmitic acid (PA) induced insulin resistance (IR) model show that (+)-ganodercin S, cochlearol F, (+)- and (-)-ganodercins V reduce the expression of collagen I as discussed by the authors .
1 citations
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TL;DR: This review deals with secondary metabolites isolated from Ganoderma and their biological significance and could lead to the discovery of hitherto unknown biologically active secondary metabolites.
240 citations
TL;DR: Biological evaluation showed that Lingzhiol or (-)-lingzhiol could selectively inhibit the phosphorylation of Smad3 in TGF-β1-induced rat renal proximal tubular cells and activate Nrf2/Keap1 in mesangial cells under diabetic conditions.
121 citations
TL;DR: The purpose of this review is to summarize and elucidate recent progress of neuroprotective effects of natural Ganoderma and its extracts.
51 citations
TL;DR: This review provides a systematic overview of the isolation, chemical structural features, biological activities, and fungal biodiversity of 1585 novel meroterpenoids from 79 genera terrestrial and marine-derived fungi including macrofungi, Basidiomycetes, in 441 research papers in 2009-2019.
Abstract: Fungal meroterpenoids are secondary metabolites from mixed terpene-biosynthetic origins. Their intriguing chemical structural diversification and complexity, potential bioactivities, and pharmacological significance make them attractive targets in natural product chemistry, organic synthesis, and biosynthesis. This review provides a systematic overview of the isolation, chemical structural features, biological activities, and fungal biodiversity of 1585 novel meroterpenoids from 79 genera terrestrial and marine-derived fungi including macrofungi, Basidiomycetes, in 441 research papers in 2009-2019. Based on the nonterpenoid starting moiety in their biosynthesis pathway, meroterpenoids were classified into four categories (polyketide-terpenoid, indole-, shikimate-, and miscellaneous-) with polyketide-terpenoids (mainly tetraketide-) and shikimate-terpenoids as the primary source. Basidiomycota produced 37.5% of meroterpenoids, mostly shikimate-terpenoids. The genera of Ganoderma, Penicillium, Aspergillus, and Stachybotrys are the four dominant producers. Moreover, about 56% of meroterpenoids display various pronounced bioactivities, including cytotoxicity, enzyme inhibition, antibacterial, anti-inflammatory, antiviral, antifungal activities. It's exciting that several meroterpenoids including antroquinonol and 4-acetyl antroquinonol B were developed into phase II clinically used drugs. We assume that the chemical diversity and therapeutic potential of these fungal meroterpenoids will provide biologists and medicinal chemists with a large promising sustainable treasure-trove for drug discovery.
49 citations
TL;DR: The broad spectrum therapeutic potential of secondary metabolites derived from Ganoderma is illustrated and supports the understanding of the main pharmacologically active compounds present in this fungus.
46 citations