Journal ArticleDOI
Ganoderma lucidum: a potent pharmacological macrofungus.
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TLDR
Ganoderma lucidum has now become recognized as an alternative adjuvant in the treatment of leukemia, carcinoma, hepatitis and diabetes, and playing a significant role in various therapeutic applications.Abstract:
Ganoderma lucidum (Ling Zhi) is a basidiomycete white rot macrofungus which has been used extensively as "the mushroom of immortality" in China, Japan, Korea and other Asian countries for 2000 years. A great deal of work has been carried out on therapeutic potential of Ganoderma lucidum. The basidiocarp, mycelia and spores of Ganoderma lucidum contain approximately 400 different bioactive compounds, which mainly include triterpenoids, polysaccharides, nucleotides, sterols, steroids, fatty acids, proteins/peptides and trace elements which has been reported to have a number of pharmacological effects including immunomodulation, anti-atherosclerotic, anti-inflammatory, analgesic, chemo-preventive, antitumor, chemo and radio protective, sleep promoting, antibacterial, antiviral (including anti-HIV), hypolipidemic, anti-fibrotic, hepatoprotective, anti-diabetic, anti-androgenic, anti-angiogenic, anti-herpetic, antioxidative and radical-scavenging, anti-aging, hypoglycemic, estrogenic activity and anti-ulcer properties. Ganoderma lucidum has now become recognized as an alternative adjuvant in the treatment of leukemia, carcinoma, hepatitis and diabetes. The macrofungus is very rare in nature rather not sufficient for commercial exploitation for vital therapeutic emergencies, therefore, the cultivation on solid substrates, stationary liquid medium or by submerged cultivation has become an essential aspect to meet the driving force towards the increasing demands in the international market. Present review focuses on the pharmacological aspects, cultivation methods and bioactive metabolites playing a significant role in various therapeutic applications.read more
Citations
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Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota.
Chih-Jung Chang,Chuan-Sheng Lin,Chia-Chen Lu,Jan Martel,Yun-Fei Ko,David M. Ojcius,Shun-Fu Tseng,Tsung-Ru Wu,Yi-Yuan Margaret Chen,John D. Young,Hsin-Chih Lai +10 more
TL;DR: The results indicate that G. lucidum and its high molecular weight polysaccharides may be used as prebiotic agents to prevent gut dysbiosis and obesity-related metabolic disorders in obese individuals.
Journal ArticleDOI
Edible Mushrooms: Improving Human Health and Promoting Quality Life
TL;DR: Mushrooms act as antibacterial, immune system enhancer and cholesterol lowering agents, and are important sources of bioactive compounds; additionally, some mushroom extracts are used to promote human health and are found as dietary supplements.
Journal ArticleDOI
Genome sequence of the model medicinal mushroom Ganoderma lucidum
Shilin Chen,Jiang Xu,Chang Liu,Yingjie Zhu,David R. Nelson,Shiguo Zhou,Chunfang Li,Lizhi Wang,Xu Guo,Yongzhen Sun,Hongmei Luo,Ying Li,Jingyuan Song,Bernard Henrissat,Anthony Levasseur,Jun Qian,Jianqin Li,Xiang Luo,Linchun Shi,Liu He,Li Xiang,Xiaolan Xu,Yunyun Niu,Qiushi Li,Mira V. Han,Haixia Yan,Jin Zhang,Haimei Chen,Aiping Lv,Zhen Wang,Mingzhu Liu,David C. Schwartz,Chao Sun +32 more
TL;DR: The sequence analysis reveals an impressive array of genes encoding cytochrome P450s (CYPs), transporters and regulatory proteins that cooperate in secondary metabolism, making this organism a potential model system for the study of secondary metabolic pathways and their regulation in medicinal fungi.
Journal ArticleDOI
The amazing potential of fungi: 50 ways we can exploit fungi industrially
Kevin D. Hyde,Jianchu Xu,Jianchu Xu,Sylvie Rapior,Rajesh Jeewon,Saisamorn Lumyong,Allen Grace Niego,Allen Grace Niego,Pranami D. Abeywickrama,Janith V. S. Aluthmuhandiram,Rashika S. Brahamanage,Siraprapa Brooks,Amornrat Chaiyasen,K. W. Thilini Chethana,Putarak Chomnunti,Clara Chepkirui,Boontiya Chuankid,Nimali I. de Silva,Mingkwan Doilom,Mingkwan Doilom,Mingkwan Doilom,Craig B. Faulds,Eleni Gentekaki,Venkat Gopalan,Pattana Kakumyan,Dulanjalee Harishchandra,Hridya Hemachandran,Sinang Hongsanan,Anuruddha Karunarathna,Anuruddha Karunarathna,Samantha C. Karunarathna,Sehroon Khan,Jaturong Kumla,Ruvishika S. Jayawardena,Jian-Kui Liu,Ning-Guo Liu,Thatsanee Luangharn,Allan Patrick G. Macabeo,Diana S. Marasinghe,Dan Meeks,Peter E. Mortimer,Peter E. Mortimer,Peter Mueller,Sadia Nadir,Sadia Nadir,Karaba N. Nataraja,Sureeporn Nontachaiyapoom,Meghan O’Brien,Watsana Penkhrue,Chayanard Phukhamsakda,Uma Shaanker Ramanan,Achala R. Rathnayaka,Resurreccion B. Sadaba,Birthe Sandargo,Binu C. Samarakoon,Danushka S. Tennakoon,Ramamoorthy Siva,Wasan Sriprom,Trichur S. Suryanarayanan,Kanaporn Sujarit,Nakarin Suwannarach,Thitipone Suwunwong,Benjarong Thongbai,Naritsada Thongklang,De-Ping Wei,S. Nuwanthika Wijesinghe,Jake Winiski,Jiye Yan,Erandi Yasanthika,Marc Stadler +69 more
TL;DR: This manuscript reviews fifty ways in which fungi can potentially be utilized as biotechnology and provides a flow chart that can be used to convince funding bodies of the importance of fungi for biotechnological research and as potential products.
Journal ArticleDOI
From 2000years of Ganoderma lucidum to recent developments in nutraceuticals.
Karen S. Bishop,Chi H.J. Kao,Yuanye Xu,Marcus P. Glucina,R. Russell M. Paterson,Lynnette R. Ferguson +5 more
TL;DR: A review of G. lucidum over the past 2000 years from prized ancient "herbal" remedy to its use in nutraceuticals and to the establishment of a 2.5 billion $ (US) industry is presented.
References
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Journal ArticleDOI
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Journal ArticleDOI
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Journal ArticleDOI
Immunomodulation and Anti-Cancer Activity of Polysaccharide- Protein Complexes
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TL;DR: Polysaccharides or polysaccharide-protein complexes are considered as multi-cytokine inducers that are able to induce gene expression of vaious immunomodulatory cytokines and cytokine receptors and act as biological response modifiers.
Journal ArticleDOI
Therapeutic Effects of Substances Occurring in Higher Basidiomycetes Mushrooms: A Modern Perspective
TL;DR: This review highlights some of the recently isolated and identified substances of higher Basidiomycetes mushrooms origin that express promising antitumor, immune modulating, cardiovascular and hypercholesterolemia, antiviral, antibacterial, and antiparasitic effects.
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Genome sequence of the model medicinal mushroom Ganoderma lucidum
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