Journal ArticleDOI
GAP-43 expression in the medulla of macaque monkeys: changes during postnatal development and the effects of early median nerve repair.
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TLDR
The results suggest that reorganization mechanisms at central terminals of peripheral nerves are very different following prenatal than postnatal nerve damage.About:
This article is published in Developmental Brain Research.The article was published on 1995-12-21. It has received 7 citations till now. The article focuses on the topics: Macaque & Cuneate nucleus.read more
Citations
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Journal ArticleDOI
The cortical somatotopic map and phantom phenomena in subjects with congenital limb atrophy and traumatic amputees with phantom limb pain
Pedro Montoya,Karin Ritter,Ellena Huse,Wolfgang Larbig,Christoph Braun,Stephanie Töpfner,Werner Lutzenberger,Wolfgang Grodd,Herta Flor,Niels Birbaumer,Niels Birbaumer +10 more
TL;DR: The assumption that congenital absence of a limb does not lead to cortical reorganization or phantom limbs is confirmed whereas traumatic amputations that are accompanied by phantom limb pain show shifts of the cortical areas adjacent to the amputation zone towards the representation of the deafferented body part.
Journal ArticleDOI
Central reorganization of sensory pathways following peripheral nerve regeneration in fetal monkeys.
TL;DR: It is shown that there is little or no topographic order in the median nerve to the hand after median nerve section and surgical repair in immature macaque monkeys, and in the same animals the representation of the reinnervated hand in primary somato-sensory cortēx is quite orderly.
Journal ArticleDOI
Initial upregulation of growth factors and inflammatory mediators during nerve regeneration in the presence of cell adhesive peptide‐incorporated collagen tubes
TL;DR: The combined results suggest that the early phase of regeneration of peripheral nerves in the presence of peptide‐incorporated collagen tubes results in the enhanced production of trophic factors by the recruited hematogenous cells and Schwann cells, which in turn help in the secretion of certain vital Trophic and tropic factors essential for early regeneration.
Journal ArticleDOI
Evidence for Altered Ca2+ Handling in Growth Associated Protein 43-Knockout Skeletal Muscle
Giusy A. Caprara,Caterina Morabito,Stefano Perni,Riccardo Navarra,Simone Guarnieri,Maria A. Mariggiò +5 more
TL;DR: GAP43 expression is involved in timing of muscle maturation in-vivo, and the emerging hypothesis indicates that GAP43 interacts with calmodulin to indirectly modulate the activities of dihydropyridine and ryanodine Ca2+ channels, from functional excitation-contraction coupling, to cell metabolism, and gene expression.
Journal ArticleDOI
Brain Reorganization and Experience
Jon H. Kaas,S. L. Florence +1 more
TL;DR: The ability to adjust to changes in the external environment is critical for learning and for recovery from brain injury as discussed by the authors, and the ability to respond in a reliable way is crucial for learning.
References
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Journal ArticleDOI
Characterization of protein F1 (47 kDa, 4.5 pI): A kinase C substrate directly related to neural plasticity
TL;DR: Evidence is provided, using two-dimensional gel electrophoresis, that only one major phosphoprotein in rat is found at 47 kDa under conditions identical to those used in that earlier study, and protein F1 is a membrane-enriched kinase C substrate whose phosphorylation is stimulated by Ca2+ and phosphatidylserine.
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Elevated synthesis of an axonally transported protein correlates with axon outgrowth in normal and injured pyramidal tracts.
K. Kalil,J. H. P. Skene +1 more
TL;DR: It is found that hamster pyramidal tract neurons synthesize an acidic, 43K protein that is transported into growing axons during the first 2 weeks of postnatal development, and then declines at least an order of magnitude by the fourth postnatal week.
Journal ArticleDOI
GAP-43 as a plasticity protein in neuronal form and repair
TL;DR: It is speculated that GAP-43 may adjust the "set point" of responsiveness for G0 stimulation by receptors, thereby altering the neuronal propensity to growth, without actually causing growth.
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Axonal transport and localization of B-50/GAP-43-like immunoreactivity in regenerating sciatic and facial nerves of the rat.
TL;DR: Investigation of regenerating sciatic and facial nerves of adult rats raised the possibility of an extra-axonal function of B-50/GAP-43, as this protein might be secreted from regenerating axons and might play a role in axon-Schwann cell interactions during axonal maturation.
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Mapping the development of the rat brain by GAP-43 immunocytochemistry.
TL;DR: The period of dense neuropil staining coincides with the formation of axonal end-arbors, the beginning of synaptogenesis, and the time at which synaptic organization can be modified by the impingent pattern of activity (i.e. the critical period).
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Postnatal changes in the number of astrocytes, oligodendrocytes, and microglia in the visual cortex (area 17) of the macaque monkey: A stereological analysis in normal and monocularly deprived animals
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