Journal ArticleDOI
GAP-43 expression in the medulla of macaque monkeys: changes during postnatal development and the effects of early median nerve repair.
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TLDR
The results suggest that reorganization mechanisms at central terminals of peripheral nerves are very different following prenatal than postnatal nerve damage.About:
This article is published in Developmental Brain Research.The article was published on 1995-12-21. It has received 7 citations till now. The article focuses on the topics: Macaque & Cuneate nucleus.read more
Citations
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Journal ArticleDOI
The cortical somatotopic map and phantom phenomena in subjects with congenital limb atrophy and traumatic amputees with phantom limb pain
Pedro Montoya,Karin Ritter,Ellena Huse,Wolfgang Larbig,Christoph Braun,Stephanie Töpfner,Werner Lutzenberger,Wolfgang Grodd,Herta Flor,Niels Birbaumer,Niels Birbaumer +10 more
TL;DR: The assumption that congenital absence of a limb does not lead to cortical reorganization or phantom limbs is confirmed whereas traumatic amputations that are accompanied by phantom limb pain show shifts of the cortical areas adjacent to the amputation zone towards the representation of the deafferented body part.
Journal ArticleDOI
Central reorganization of sensory pathways following peripheral nerve regeneration in fetal monkeys.
TL;DR: It is shown that there is little or no topographic order in the median nerve to the hand after median nerve section and surgical repair in immature macaque monkeys, and in the same animals the representation of the reinnervated hand in primary somato-sensory cortēx is quite orderly.
Journal ArticleDOI
Initial upregulation of growth factors and inflammatory mediators during nerve regeneration in the presence of cell adhesive peptide‐incorporated collagen tubes
TL;DR: The combined results suggest that the early phase of regeneration of peripheral nerves in the presence of peptide‐incorporated collagen tubes results in the enhanced production of trophic factors by the recruited hematogenous cells and Schwann cells, which in turn help in the secretion of certain vital Trophic and tropic factors essential for early regeneration.
Journal ArticleDOI
Evidence for Altered Ca2+ Handling in Growth Associated Protein 43-Knockout Skeletal Muscle
Giusy A. Caprara,Caterina Morabito,Stefano Perni,Riccardo Navarra,Simone Guarnieri,Maria A. Mariggiò +5 more
TL;DR: GAP43 expression is involved in timing of muscle maturation in-vivo, and the emerging hypothesis indicates that GAP43 interacts with calmodulin to indirectly modulate the activities of dihydropyridine and ryanodine Ca2+ channels, from functional excitation-contraction coupling, to cell metabolism, and gene expression.
Journal ArticleDOI
Brain Reorganization and Experience
Jon H. Kaas,S. L. Florence +1 more
TL;DR: The ability to adjust to changes in the external environment is critical for learning and for recovery from brain injury as discussed by the authors, and the ability to respond in a reliable way is crucial for learning.
References
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Journal ArticleDOI
GAP-43 distribution is correlated with development of growth cones and presynaptic terminals.
TL;DR: Mini-explant cerebellar cultures were examined with light microscopic immunocytochemistry, GAP-43 label of plasma membrane was highest at the periphery of the radial axonal outgrowth, suggesting that addition of G AP-43 to the plasma membrane can occur in the distal axon or at the growth cone.
Book
Plasticity in the Somatosensory System of Developing and Mature Mammals ― The Effects of Injury to the Central and Peripheral Nervous System
Peter J. Snow,Peter Wilson +1 more
Journal ArticleDOI
Age-dependent differences in reorganization of primary somatosensory cortex following low thoracic (T12) spinal cord transection in cats
PA McKinley,JL Smith +1 more
TL;DR: It is suggested that the various patterns of cortical organization observed at different ages reflect different developmental processes that are active at the time of transection, and often, in major denervations such as spinal cord transections, a significant component of the reorganization occurs at synaptic levels below the cortex in young animals.
Journal ArticleDOI
Development of tactile discrimination capacity in Macaca mulatta. I. Normal infants.
TL;DR: Infant macaques between the ages of 7 and 25 weeks of age were trained on a series of manual tactile discrimination tasks, suggesting an improved efficiency in size discrimination capacity over the first 6 months of life.
Journal ArticleDOI
Anatomic Distribution of the Growth-Associated Protein GAP-43 in the Developing Human Brainstem
TL;DR: Persistence of GAP-43 staining in the corticospinal tract past the fetal period suggests that this tract remains in a plastic state beyond initial axonal elongation, and intense immunostaining in visceral-related nuclei into adulthood suggests that these regions may continue to undergo synaptic reorganization.
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Postnatal changes in the number of astrocytes, oligodendrocytes, and microglia in the visual cortex (area 17) of the macaque monkey: A stereological analysis in normal and monocularly deprived animals
John O'Kusky,Marc Colonnier +1 more
The postnatal development of somatosensory callosal connections after partial lesions of somatosensory areas.
R. Caminiti,Giorgio M. Innocenti +1 more