Gasdermins: Effectors of Pyroptosis
Stephen B. Kovacs,Edward A. Miao +1 more
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TLDR
The current understanding of pyroptosis as well as current knowledge of the gasdermin family are reviewed.About:
This article is published in Trends in Cell Biology.The article was published on 2017-09-01 and is currently open access. It has received 691 citations till now. The article focuses on the topics: Pyroptosis.read more
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Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria (111.33)
Edward A. Miao,Irina A. Leaf,Piper M. Treuting,Dat P. Mao,Anasuya Sarkar,Mark D. Wewers,Alan Aderem +6 more
TL;DR: It is demonstrated that activation of caspase-1 clears intracellular bacteria in vivo independently of IL-1β and IL-18 and establishes pyroptosis as an efficient mechanism of bacterial clearance by the innate immune system.
Journal ArticleDOI
The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages.
Charles L. Evavold,Jianbin Ruan,Yunhao Tan,Shiyu Xia,Hao Wu,Jonathan C. Kagan,Jonathan C. Kagan +6 more
TL;DR: It is reported that the pyroptosis regulator gasdermin D (GSDMD) was necessary for IL‐1 secretion from living macrophages that have been exposed to inflammasome activators, such as bacteria and their products or host‐derived oxidized lipids.
Journal ArticleDOI
Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.
Pontus Orning,Pontus Orning,Dan Weng,Dan Weng,Kristian K. Starheim,Kristian K. Starheim,Dmitry Ratner,Zachary Best,Bettina L. Lee,Alexandria Brooks,Shiyu Xia,Hao Wu,Michelle A. Kelliher,Scott B. Berger,Peter J. Gough,John Bertin,Megan K. Proulx,Jon D. Goguen,Nobuhiko Kayagaki,Katherine A. Fitzgerald,Katherine A. Fitzgerald,Egil Lien,Egil Lien +22 more
TL;DR: Caspase-8 acts as a regulator of GSDMD-driven cell death and contributes to the NLRP3 inflammasome–dependent release of interleukin-1 β (IL-1β) and IL-18, establishing the importance of TAK1 and IKK activity in the control of G SDMD cleavage and cytotoxicity.
Journal ArticleDOI
Pyroptosis: mechanisms and diseases.
TL;DR: It is described that pyroptosis is a double-edged sword for tumors and the rational use of this dual effect will help to further explore the formation and development of tumors, and provide ideas for patients to develop new drugs based on pyroPTosis.
Journal ArticleDOI
PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis
Junwei Hou,Rongce Zhao,Rongce Zhao,Rongce Zhao,Weiya Xia,Chiung Wen Chang,Yun You,Jung Mao Hsu,Jung Mao Hsu,Lei Nie,Yeh Chen,Yu Chuan Wang,Chunxiao Liu,Wei Jan Wang,Wei Jan Wang,Yun Wu,Baozhen Ke,Jennifer L. Hsu,Kebin Huang,Kebin Huang,Zu Ye,Yi Yang,Xianghou Xia,Yintao Li,Chia Wei Li,Bin Shao,Bin Shao,John A. Tainer,Mien Chie Hung,Mien Chie Hung,Mien Chie Hung +30 more
TL;DR: Findings identify a non-immune checkpoint function of PD-L1 and provide an unexpected concept that GSDMC/Caspas-8 mediates non-canonical pyroptosis pathway in cancer cells, causing tumor necrosis.
References
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Nathan C. Shaner,Robert E. Campbell,Robert E. Campbell,Paul Steinbach,Ben N G Giepmans,Amy E. Palmer,Roger Y. Tsien +6 more
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Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Jianjin Shi,Yue Zhao,Kun Wang,Xuyan Shi,Wang Yue,Huanwei Huang,Yinghua Zhuang,Tao Cai,Fengchao Wang,Feng Shao +9 more
TL;DR: Gasdermin D (Gsdmd) is identified by genome-wide clustered regularly interspaced palindromic repeat-Cas9 nuclease screens of caspase-11- and caspasing-1-mediated pyroptosis in mouse bone marrow macrophages to offer insight into inflammasome-mediated immunity/diseases and change the understanding of pyroPTosis and programmed necrosis.
Journal ArticleDOI
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Nobuhiko Kayagaki,Irma B. Stowe,Bettina L. Lee,Karen O'Rourke,Keith R. Anderson,Søren Warming,Trinna L. Cuellar,Benjamin Haley,Merone Roose-Girma,Qui T. Phung,Peter Liu,Jennie R. Lill,Hong Li,Jiansheng Wu,Sarah K. Kummerfeld,Juan Zhang,Wyne P. Lee,Scott J. Snipas,Guy S. Salvesen,Lucy X. Morris,Linda Fitzgerald,Yafei Zhang,Edward M. Bertram,Christopher C. Goodnow,Christopher C. Goodnow,Christopher C. Goodnow,Vishva M. Dixit +26 more
TL;DR: It is shown that gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1β maturation and a key mediator of the host response against Gram-negative bacteria.
Journal ArticleDOI
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
Xing Liu,Zhibin Zhang,Zhibin Zhang,Jianbin Ruan,Jianbin Ruan,Youdong Pan,Venkat Giri Magupalli,Venkat Giri Magupalli,Hao Wu,Hao Wu,Judy Lieberman,Judy Lieberman +11 more
TL;DR: It is shown that GSDMD-NT oligomerizes in membranes to form pores that are visible by electron microscopy and kills cell-free bacteria in vitro and may have a direct bactericidal effect within the cytosol of host cells, but the importance of direct bacterial killing in controlling in vivo infection remains to be determined.
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A large-scale, consortium-based genomewide association study of asthma.
Miriam F. Moffatt,Ivo Gut,Florence Demenais,David P. Strachan,Emmanuelle Bouzigon,Simon Heath,Erika von Mutius,Martin Farrall,Mark Lathrop,William O.C.M. Cookson +9 more
TL;DR: A few common alleles are associated with disease risk at all ages and suggest a role for communication of epithelial damage to the adaptive immune system and activation of airway inflammation in asthma.
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