GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer
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..., 2008), as well as previous reports of GATA6 loss in basal-like tumors with poor outcome (Martinelli et al., 2016)....
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Cites result from "GATA6 regulates EMT and tumour diss..."
...Consistent with previous studies in resected PDAC (9, 12, 13, 25), tumors with the basal-like subtype had significantly lower levels of GATA6 expression compared to classical subtype tumors (Supplementary Fig....
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...Our results and others (25) strongly support using GATA6 expression as a surrogate biomarker to differentiate tumor RNA subtypes, an important translational advance that can be used in the clinic by pathologists using fresh or archival tumors....
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...This study also showed that GATA6-low cell lines derived from patient-derived xenograftswere particularly resistant to 5-FUbut not gemcitabine (30)....
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"GATA6 regulates EMT and tumour diss..." refers background in this paper
...Significant peaks of GATA6 binding were identified with MACS (1) v1....
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