Gender differences in the association of hazardous alcohol use with hypertension in an urban cohort of people living with HIV in South Florida.
Maria Jose Miguez-Burbano,Clery Quiros,John E. Lewis,Luis Espinoza,Robert L. Cook,Allison B. Trainor,Erika Richardson,Deshratn Asthana +7 more
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TLDR
Excessive hypertension burden in this population and its association with HAU and sub-optimal care indicate the need for preventive and educational intervention in PLWH.Abstract:
Objective
Industrialized countries are currently experiencing an epidemic of high blood pressure (HBP) extending to people living with HIV (PLWH). Given the prevalence of hazardous alcohol use (HAU), this study examines the relationship between alcohol consumption and hypertension in PLWH. Including a gender analysis is critical, given the high rates of HAU and HIV among females.
Method
We followed PLWH including both HAU and non-HAU (200 each). Participants were assessed twice for body weight, blood pressure, alcohol consumption, and other BP-associated lifestyle factors. High blood pressure (defined as systolic/diastolic blood pressure above 140/90 mmHg and/or treatment of HBP) was the primary outcome.
Results
Overall prevalence of hypertension was 38% and higher among HAU compared to non-HAU (42% vs. 34%, p = 0.02). Less than half with HBP (42%) were receiving treatment for hypertension. Overall, males had a 50% higher risk of HBP than women (odds ratio: 1.5, 95% CI: 1–2.6, p = 0.05). However among HAU, females were twice as likely to suffer HBP as their male counterparts (95% CI: 1–3.9, p = 0.02). Those HAU who preferred liquor, versus wine, had higher adjusted mean BP (132.6±18 vs. 122.3±14 mm Hg, p = 0.05). Additional analyses indicated that consumption of >1 standard drink of liquor or beer/day was associated with HBP. Risk of hypertension was noted in those with daily consumption of >3 glasses of wine. For those reporting <1 drink per day, the odds ratio of having HBP was 0.97 (CI: 0.6–0.99, p = 0.05). Factors associated with hypertension in the multivariate model included increased age, gender, BMI, HAU particularly of liquor, and smoking.
Conclusions
Excessive hypertension burden in this population and its association with HAU and sub-optimal care indicate the need for preventive and educational intervention in PLWH. Analyses highlight the necessity of gender and type-of-beverage specific approaches.read more
Citations
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Journal ArticleDOI
Hypertension in people living with HIV.
TL;DR: The burden of hypertension among people living with HIV is high and its pathophysiology most likely multifactorial, and efforts should be made to improve hypertension management as per existing clinical guidelines in order to safeguard cardiovascular health and quality of life in PLHIV.
Journal Article
Burden, Determinants, and Pharmacological Management of Hypertension in HIV-Positive Patients and Populations: A Systematic Narrative Review.
Kim A. Nguyen,Nasheeta Peer,Nasheeta Peer,Edward J Mills,Andre Pascal Kengne,Andre Pascal Kengne +5 more
TL;DR: The clinical management of hypertension in HIV-positive patients is similar to those with hypertension in the general population; however, additional considerations should be given to potential drug interactions between antihypertensive agents and antiretroviral drugs to inform the clinician's selection of these therapies.
Journal ArticleDOI
Protective Effects of Tinospora cordifolia on Hepatic and Gastrointestinal Toxicity Induced by Chronic and Moderate Alcoholism.
Bhawana Sharma,Rajesh Dabur +1 more
TL;DR: Overall data depict that moderate alcohol intake is also hepatotoxic and decreases intestinal absorption, however, TCE treatment effectively increased the intestinal absorption and retaining power of liver that regulated alcohol-induced multivitamin deficiency.
Journal ArticleDOI
Is burden of disease differentially linked to spirits? A systematic scoping review and implications for alcohol policy.
Jürgen Rehm,Omer S. M. Hasan +1 more
TL;DR: There is no conclusive evidence for spirits being associated with more harm, but some evidence supports for certain outcomes such as injuries and poisonings a potential excess risk for spirits consumption due to rapid ethanol intake and intoxication.
Journal ArticleDOI
Cumulative HIV Viremia Copy-Years and Hypertension in People Living with HIV.
TL;DR: Investigating the relationship between HIV viral load and hypertension using viremia copy-years (VCY), a cumulative measure of HIV plasma viral burden, supports the significance of continuous viral suppression in hypertension prevention among PLWH.
References
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Alcohol and blood pressure: the INTERSALT study
Michael Marmot,Perry M. Elliott,Perry M. Elliott,Martin J. Shipley,Martin J. Shipley,Alan R. Dyer,Hirotsugu Ueshima,Hirotsugu Ueshima,D G Beevers,D G Beevers,R. Stamler,R. Stamler,H. Kesteloot,H. Kesteloot,G Rose,G Rose,Jeremiah Stamler +16 more
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Journal ArticleDOI
Association between highly active antiretroviral therapy and hypertension in a large cohort of men followed from 1984 to 2003.
Eric C. Seaberg,Alvaro Muñoz,Ming Lu,Roger Detels,Joseph B. Margolick,Sharon A. Riddler,Carolyn Williams,John P. Phair +7 more
TL;DR: Prolonged HAART use was significantly associated with a higher prevalence of systolic and diastolic hypertension, suggesting that individuals taking HAART may be at increased risk of developing hypertension-related conditions and underscores the importance of blood pressure monitoring among these individuals.
Journal ArticleDOI
Hypertension among HIV patients: Prevalence and relationships to insulin resistance and metabolic syndrome
Carmine Gazzaruso,Raffaele Bruno,Adriana Garzaniti,Stefano Giordanetti,Pietro Fratino,Paolo Sacchi,Gaetano Filice +6 more
TL;DR: It is shown that hypertension is frequent in HIV patients on HAART and that hypertension appears to be linked to insulin resistance; in particular, hypertension seems to be a part of the metabolic syndrome.
Journal ArticleDOI
Relationship of Alcohol Drinking Pattern to Risk of Hypertension: A Population-Based Study
Saverio Stranges,Tiejian Wu,Joan M. Dorn,Jo L. Freudenheim,Paola Muti,Eduardo Farinaro,Marcia Russell,Thomas H. Nochajski,Maurizio Trevisan +8 more
TL;DR: Investigation of current alcohol consumption and aspects of drinking pattern in a sample of 2609 white men and women from western New York found drinking outside meals appears to have a significant effect on hypertension risk independent of the amount of alcohol consumed.