Gene-environment interactions for complex traits: Definitions, methodological requirements and challenges
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Cites background from "Gene-environment interactions for c..."
...Thus, an individual's genetic profile could determine if he/ she has a greater or lesser susceptibility to a disease under the influences of the same environment (Dempfle et al., 2008)....
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Cites background from "Gene-environment interactions for c..."
...SUMMARY Nearly all GWAS to date have concentrated on detecting and characterizing main effects of genes and have underemphasized the potential role the environment plays in modifying genetic risk [Clayton and McKeigue, 2001; Dempfle et al., 2008; Martinez, 2008]....
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...Nearly all GWAS to date have concentrated on detecting and characterizing main effects and have not fully explored the potential role environmental factors play in modifying genetic risk [Clayton and McKeigue, 2001; Dempfle et al., 2008; Martinez, 2008]....
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