Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance
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...And in the second, we found a drug capable of reversing glucocorticoid resistance in acute lymphoblastic leukaemia (ALL) cell...
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...Wei and colleagues (166) used a chemical genomic screen to identify several compounds, including anthracycline chemotherapeutics (e....
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References
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"Gene expression-based chemical geno..." refers background in this paper
...Defective apoptosis is a hallmark of cancer (Hanahan and Weinberg, 2000), and the ability to activate the apoptotic program is an important determinant of efficacy for anticancer drugs (Fesik, 2005; Reed, 1995)....
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"Gene expression-based chemical geno..." refers background in this paper
...Members of the BCL2 protein family play critical roles in the intrinsic apoptotic program controlling whether an apoptotic signal will result in cell death (Danial and Korsmeyer, 2004)....
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...In response to various apoptotic stimuli, proapoptotic BH3-only members induce activation of BAX and BAK, and cytochrome c release from mitochondria, thus triggering activation of caspases through the apoptosome complex (Danial and Korsmeyer, 2004)....
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...Conversely, antiapoptotic members such BCL2, BCL-XL, or MCL1 antagonize BH3-only proteins, thereby inhibiting BAX and BAK activation and apoptosis (Danial and Korsmeyer, 2004)....
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"Gene expression-based chemical geno..." refers background or methods in this paper
...scribed (Lamb et al., 2006) and combined to produce a ‘‘connectivity score....
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...To test this hypothesis, we made use of a database of 453 genome-wide expression profiles derived from the treatment of a variety of human cell lines with 164 bioactive small molecules, the majority of which are established pharmaceuticals or compounds with known activities, referred to as the Connectivity Map (Table S1) (Lamb et al., 2006)....
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