Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas.
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4,215 citations
Cites result from "Gene expression profiling and histo..."
...A previous TNBC study identified 5 distinct hierarchical clusters in which 91% (88 of 97) of TNBCs identified by IHC correlated to the basal-like subtype (42)....
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3,125 citations
2,939 citations
1,269 citations
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Cites methods from "Gene expression profiling and histo..."
...Predictors of Response The TNBCs tend to be classified as basal-like in gene expression array hierarchical cluster analysis using the intrinsic genes.(12,22) We determined the intrinsic subtype of all cases with adequate material (n 24) by co-clustering these cases with a reference set of tumors for which intrinsic subtype had been determined independently (Supplemental Fig 1, Supplemental Methods)....
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References
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"Gene expression profiling and histo..." refers background or methods in this paper
...[4] as describing a subgroup of tumors that was defined by their great similarity in overall gene-expression pattern of the 'intrinsic gene subset' when unsupervised hierarchical clustering was applied....
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...[3-6] to define basallike, luminal A-like, luminal B-like, ERBB2-like and normal breast-like tumor classes on the basis of hierarchical clustering and correlation to the class centroids; using the intrinsic gene list as recently updated by Hu et al....
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...were the first to show that breast carcinomas can also be subdivided based on gene-expression analysis [3-6]....
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...This category of breast carcinomas has been shown to stand out from the other breast cancer subtypes by a unique geneexpression profile (basal-like subtype) revealed by geneexpression profiling studies [3-6,24-26]....
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...The largest difference in overall gene-expression profile is observed between tumors that are estrogen receptor (ER) positive and those that are ER negative [4]....
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12,102 citations
"Gene expression profiling and histo..." refers methods in this paper
...Supervised classification was performed on the 71 samples with follow-up data using SAM-software [22] developed by Tusher et al. We used the settings in the software for cen- Page 3 of 14 (page number not for citation purposes) sored survival data....
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...Supervised classification was performed on the 71 samples with follow-up data using SAM-software [22] developed by Tusher et al....
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10,791 citations
"Gene expression profiling and histo..." refers background or methods in this paper
...[3-6] to define basallike, luminal A-like, luminal B-like, ERBB2-like and normal breast-like tumor classes on the basis of hierarchical clustering and correlation to the class centroids; using the intrinsic gene list as recently updated by Hu et al....
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...were the first to show that breast carcinomas can also be subdivided based on gene-expression analysis [3-6]....
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...This category of breast carcinomas has been shown to stand out from the other breast cancer subtypes by a unique geneexpression profile (basal-like subtype) revealed by geneexpression profiling studies [3-6,24-26]....
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...studied larger series of tumors (n = 416 cases) and refined the composition of the intrinsic gene set [3,5,6]....
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...It is believed that basal-like tumors constitute a homogenous sub-group of breast carcinomas [3-8]....
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9,664 citations
"Gene expression profiling and histo..." refers background in this paper
...Specific subgroups of triple-negative tumors may be formed by medullary and atypical medullary cancers [12,37-39]....
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...We have previously identified a 70-gene prognosis profile [12,13]....
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