Gene expression regulation mediated through reversible m 6 A RNA methylation
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...…5-methylcytidine (Hussain et al., 2013; Squires et al., 2012), pseudouridine (Carlile et al., 2014; Schwartz et al., 2014), and N6-methyladenosinde (Fu et al., 2014; Lee et al., 2014; Meyer and Jaffrey, 2014; Nilsen, 2014; Wang and He, 2014a), have emerged as potential new mechanisms of…...
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...The m6A-modified transcripts inherently possess shorter half-lives than non-methylated ones in HeLa cells (Fu et al., 2014)....
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...However, as indicated by most recent evidence, dynamic modifications of mRNA, including 5-methylcytidine (Hussain et al., 2013; Squires et al., 2012), pseudouridine (Carlile et al., 2014; Schwartz et al., 2014), and N6-methyladenosinde (Fu et al., 2014; Lee et al., 2014; Meyer and Jaffrey, 2014; Nilsen, 2014; Wang and He, 2014a), have emerged as potential new mechanisms of post-transcriptional gene regulation....
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...Article N6-methyladenosine Modulates Messenger RNA...
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...The m6A-modified RNAs tend to be dynamic and possess relatively shorter half-lives (Batista et al., 2014; Fu et al., 2014; Wang et al., 2014b)....
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..., 2013), both belong to the AlkB family and catalyze m(6)A demethylation in a Fe(II)- and a-ketoglutarate-dependent manner, and are referred to as m(6)A ‘‘erasers’’ (Fu et al., 2014; Yue et al., 2015)....
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...FTO and ALKBH5, the second RNA demethylase identified in 2013 (Zheng et al., 2013), both belong to the AlkB family and catalyze m6A demethylation in a Fe(II)- and a-ketoglutarate-dependent manner, and are referred to as m6A ‘‘erasers’’ (Fu et al., 2014; Yue et al., 2015)....
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...G[G > A]m6AC[U > A > C] (Fu et al., 2014; Meyer and Jaffrey, 2014; Niu et al., 2013; Yue et al., 2015)....
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