Gene Ontology: tool for the unification of biology
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...This enables them to contribute to the work of the gene ontology (GO) consortium (9) by assigning GO terms during the annotation process as they extract information related to each of the GO ontologies, i....
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Cites background or methods from "Gene Ontology: tool for the unifica..."
...To extract gene sets from gene expression data deposited in the GEO (29), we established a crowdsourcing microtask project that asks participants to extract gene sets from GEO for the following categories: (1) single-gene perturbations in mammalian cells; (2) comparison of diseased versus normal tissues; (3) single-drug perturbations in mammalian cells; (4) perturbations applied to MCF7 cells; (5) comparison between young and old mammalian tissues; (6) endogenous ligand perturbations of mammalian cells; and (7) comparison of before and after pathogen infection of human cells....
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...The Gene Ontology (GO), which was first published in the year 2000 (1), introduced the concept of associating a collection of genes with a functional biological term in a systematic way....
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References
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"Gene Ontology: tool for the unifica..." refers background in this paper
...2 ); and the fruitfly Drosophila melanogaster , completed earlier this yea...
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5,176 citations
"Gene Ontology: tool for the unifica..." refers background in this paper
...Another use for GO ontologies that is gaining rapid adherence is the annotation of gene-expression data, especially after these have been clustered by similarities in pattern of gene expressio...
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4,254 citations
"Gene Ontology: tool for the unifica..." refers background in this paper
...Functional conservation requires a common language for annotation Nowhere is the impact of the grand biological unification more evident than in the eukaryotes, where the genomic sequences of three model systems are already available (budding yeast, Saccharomyces cerevisiae , completed in 1996 (ref...
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