Gene therapy clinical trials worldwide to 2012 - an update
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...At the time of our June 2012 update, we had entries on 1843 trials, undertaken in 31 countries, that had been approved, initiated or completed worldwide.(2) Looking further back, there were 1309 trials in 28 countries at the time of our 2007 review(3) and 918 trials in 24 countries at the start of 2004....
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References
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"Gene therapy clinical trials worldw..." refers background in this paper
...A form of transcriptional inhibition initially observed in plants, RNAi was first identified as being caused by complementary double-stranded RNA (dsRNA) in nematode worms by Fire et al. in 1998 [ 36 ]....
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"Gene therapy clinical trials worldw..." refers background in this paper
...integration near the LMO2 proto-oncogene promoter, a phenomenon known as insertional mutagenesis, leading to aberrant transcription and expression of LMO2 [10,11]....
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...The preliminary data implicate an insertion upstream of LMO2 and additional chromosomal mutations reminiscent of the genotoxic events occurring in the SCID-X1 trials....
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...This was shown to be related to retrovirus vector Copyright © 2013 John Wiley & Sons, Ltd. integration near the LMO2 proto-oncogene promoter, a phenomenon known as insertional mutagenesis, leading to aberrant transcription and expression of LMO2 [10,11]....
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Additional excerpts
...42 10 transduced T cells [30]....
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