Journal ArticleDOI
General method of diastereo- and enantioselective synthesis of β-hydroxy-α-amino acids by condensation of aldehydes and ketones with glycine
Yuri N. Belokon,A. G. Bulychev,S. V. Vitt,Yu. T. Struchkov,Andrei S. Batsanov,Tatiana V. Timofeeva,V. A. Tsyryapkin,M. G. Ryzhov,L. A. Lysova,Vladimir I. Bakhmutov,V. M. Belikov +10 more
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Synthese en particulier de serine, methylenedioxy-3,4 phenylserine, phenyl-serine et methylenediosymbolic acid (MDE).Abstract:
Synthese en particulier de serine, hydroxy-3 valine, hydroxy-2 phenylserine, phenylserine et methylenedioxy-3,4 phenylserineread more
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Recent developments in the stereoselective synthesis of α-aminoacids
Journal ArticleDOI
Addition of chiral glycine, methionine, and vinylglycine enolate derivatives to aldehydes and ketones in the preparation of enantiomerically pure α-amino-β-hydroxy acids
TL;DR: Information suggesting that both steric and stereoelectronic effects are responsible for the good stereoselectivities observed is presented, suggesting that the title amino acids are of high enantiomeric purity.
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Resolution and use in α-amino acid synthesis of imidazolidinone glycine derivatives
Robert Fitzi,Dieter Seebach +1 more
TL;DR: In this article, the imidazolidinones obtained from pivalaldehyde and glycine amides are resolved efficiently by crystallization of diastereoisomeric ammonium salts with chiral acids (mandelates and a gulonate respectively).
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Approaches to Obtaining Fluorinated α-Amino Acids.
Johann Moschner,Valentina Stulberg,Rita Fernandes,Susanne Huhmann,Jakob Leppkes,Beate Koksch +5 more
TL;DR: Synthetic access to fluorinated versions of alkyl, cyclic, aromatic amino acids, and also nickel-complexes to access them are described to make the information easily accessible to the reader.
Journal ArticleDOI
Enzymatic Synthesis of β-Hydroxy-α-amino Acids Based on Recombinant d- and l-Threonine Aldolases
TL;DR: To exploit the enzymatic method for the synthesis of β-hydroxy-α-amino acids, the genes coding for the Escherichia coli LTA and Xanthomonus oryzae d-threonine aldolase were cloned and overexpressed in E. coli through primer-directed polymerase chain reactions.