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Generalized Linear Models
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The article was published on 2003-08-25 and is currently open access. It has received 10034 citations till now. The article focuses on the topics: Generalized linear model.read more
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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
TL;DR: This work presents DESeq2, a method for differential analysis of count data, using shrinkage estimation for dispersions and fold changes to improve stability and interpretability of estimates, which enables a more quantitative analysis focused on the strength rather than the mere presence of differential expression.
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Distributed Optimization and Statistical Learning Via the Alternating Direction Method of Multipliers
TL;DR: It is argued that the alternating direction method of multipliers is well suited to distributed convex optimization, and in particular to large-scale problems arising in statistics, machine learning, and related areas.
Journal ArticleDOI
Differential expression analysis for sequence count data.
Simon Anders,Wolfgang Huber +1 more
TL;DR: A method based on the negative binomial distribution, with variance and mean linked by local regression, is proposed and an implementation, DESeq, as an R/Bioconductor package is presented.
Journal ArticleDOI
Missing data: Our view of the state of the art.
Joseph L. Schafer,John W. Graham +1 more
TL;DR: 2 general approaches that come highly recommended: maximum likelihood (ML) and Bayesian multiple imputation (MI) are presented and may eventually extend the ML and MI methods that currently represent the state of the art.
Journal ArticleDOI
Variable Selection via Nonconcave Penalized Likelihood and its Oracle Properties
Jianqing Fan,Runze Li +1 more
TL;DR: In this article, penalized likelihood approaches are proposed to handle variable selection problems, and it is shown that the newly proposed estimators perform as well as the oracle procedure in variable selection; namely, they work as well if the correct submodel were known.