Journal ArticleDOI
Generation of bioactive prolyl-hydroxyproline (Pro-Hyp) by oral administration of collagen hydrolysate and degradation of endogenous collagen
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TLDR
The facts indicate that Pro‐Hyp is generated by the degradation of endogenous collagen to activate cells involved in tissue reconstruction, and the endogenous bioactive peptide can be provided by ingestion of collagen hydrolysate.Abstract:
Hydroxyproline‐containing di‐ and tripeptides increase in human blood plasma after ingestion of collagen hydrolysate in a dose‐dependent manner. Prolyl‐hydroxyproline (Pro‐Hyp) and hydroxyprolyl‐glycine (Pro‐Gly) are the main food‐derived collagen peptides present in human blood plasma. Pro‐Hyp increases the number of fibroblasts migrating from the mouse skin and enhances the growth of fibroblasts attached to the collagen gel. Pro‐Hyp is also generated from endogenous collagen in the granulation tissue in mice skin and ear with dermatitis, while it does not increase in the normal tissues of the same animal. However, Hyp‐Gly does not increase in all tissues. These facts indicate that Pro‐Hyp is generated by the degradation of endogenous collagen to activate cells involved in tissue reconstruction. Orally administered Pro‐Hyp is deposited in animal organs even after clearance of Pro‐Hyp from blood. Thus, the endogenous bioactive peptide can be provided by ingestion of collagen hydrolysate.read more
Citations
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Journal ArticleDOI
Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health.
TL;DR: Dietary taurine, creatine, carnosine, anserine,Anserine and 4-hydroxyproline are beneficial for preventing and treating obesity, cardiovascular dysfunction, and ageing-related disorders, as well as inhibiting tumorigenesis, improving skin and bone health, ameliorating neurological abnormalities, and promoting well being in infants, children and adults.
Journal ArticleDOI
Collagen-Derived Di-Peptide, Prolylhydroxyproline (Pro-Hyp): A New Low Molecular Weight Growth-Initiating Factor for Specific Fibroblasts Associated With Wound Healing.
TL;DR: Pro-Hyp is a low molecular weight growth-initiating factor for specific fibroblasts that is involved in the wound healing process and has therapeutic potential for chronic wounds.
Journal ArticleDOI
Comprehensive identification of native medium-sized and short bioactive peptides in sea bass muscle.
Andrea Cerrato,Sara Elsa Aita,Chiara Cavaliere,Aldo Laganà,Aldo Laganà,Carmela Maria Montone,Susy Piovesana,Riccardo Zenezini Chiozzi,Anna Laura Capriotti +8 more
TL;DR: Native peptides from sea bass muscle were analyzed by two different approaches: medium-sized peptides by peptidomics analysis, whereas short peptide sequences by suspect screening analysis employing an inclusion list of exact m/z values of all possible amino acid combinations.
Journal ArticleDOI
Acceleration of Skin Wound-Healing Reactions by Autologous Micrograft Tissue Suspension.
TL;DR: Findings indicated that MG accelerated a series of wound-healing reactions and could be useful for treating intractable wounds in clinical situations.
Journal ArticleDOI
The dipeptide prolyl-hydroxyproline promotes cellular homeostasis and lamellipodia-driven motility via active β1-integrin in adult tendon cells
Kentaro Ide,Sanai Takahashi,Keiko Sakai,Yuki Taga,Tomonori Ueno,David Dickens,Rosalind E. Jenkins,Francesco Falciani,Takako Sasaki,Kazuhiro Ooi,Shuichi Kawashiri,Kazunori Mizuno,Shunji Hattori,Takao Sakai +13 more
TL;DR: In this article, the dipeptide prolyl-4-hydroxyproline (Pro-Hyp) exhibits pronounced effects on mouse tendon cells, with increased directional persistence and significantly increased directed motility and migration velocity.
References
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Book ChapterDOI
Biochemical and Biological Attributes of Matrix Metalloproteinases.
Ning Cui,Min Hu,Raouf A. Khalil +2 more
TL;DR: Matrix metalloproteinases play a role in tissue remodeling during various physiological processes such as angiogenesis, embryogenesis, morphogenesis, and wound repair, as well as in pathological conditions such as myocardial infarction, fibrotic disorders, osteoarthritis, and cancer.
Journal ArticleDOI
Identification of Food-Derived Collagen Peptides in Human Blood after Oral Ingestion of Gelatin Hydrolysates
Koji Iwai,Takanori Hasegawa,Yasuki Taguchi,Fumiki Morimatsu,Kenji Sato,Yasushi Nakamura,Akane Higashi,Yasuhiro Kido,Nakabo Yukihiro,Kozo Ohtsuki +9 more
TL;DR: Several food-derived collagen peptides in human blood after oral ingestion of some gelatin hydrolysates were identified as Pro-Hyp, and small but significant amounts of Ala-hyp, Ala-Hyp-Gly, Pro- hyp, Leu- Hyp, Ile-Hyp and Phe-Hyp were contained.
Journal ArticleDOI
Comparison of Quantity and Structures of Hydroxyproline-Containing Peptides in Human Blood after Oral Ingestion of Gelatin Hydrolysates from Different Sources
TL;DR: The quantity and structure of Hyp-containing peptides in human blood after oral administration of gelatin hydrolysate depends on the gelatin source.
Journal ArticleDOI
Effect of Prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin.
Yasutaka Shigemura,Koji Iwai,Fumiki Morimatsu,Takaaki Iwamoto,Toshio Mori,Chikako Oda,Toshio Taira,Eun Young Park,Yasusi Nakamura,Kenji Sato +9 more
TL;DR: It is suggested that prolyl-hydroxyproline (Pro-Hyp) might stimulate the growth of fibroblasts in the skin and consequently increase the number of fibrablasts migrating from the skin.
Journal ArticleDOI
Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts
Hiroki Ohara,Satomi Ichikawa,Hitoshi Matsumoto,Minoru Akiyama,Norihiro Fujimoto,Takashi Kobayashi,Shingo Tajima +6 more
TL;DR: The results suggest that Pro‐Hyp stimulates both cell mitotic activity and hyaluronic acid synthesis, which is mediated by activation of HAS2 transcription.