Journal ArticleDOI
Generation of mutator mutants during carcinogenesis.
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TLDR
It is emphasized that simple random point mutations can drive carcinogenesis and highlight new emerging pathways that generate these mutations.About:
This article is published in DNA Repair.The article was published on 2006-03-07. It has received 54 citations till now. The article focuses on the topics: Point mutation & Mutation.read more
Citations
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Journal ArticleDOI
Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer
TL;DR: Synthetic oleanane triterpenoids and rexinoids are two new classes of multifunctional drugs that have unique molecular and cellular mechanisms of action and might prove to be synergistic with standard anti-cancer treatments.
Journal ArticleDOI
DNA precursor metabolism and genomic stability
TL;DR: This review focuses on developments since 1994, when the field was last reviewed comprehensively, and focuses on novel aspects of dNTP pool regulation, metabolism and hypermutagenesis in the mitochondrial genome.
DissertationDOI
Specific expression of activation-induced cytidine deaminase (AID) , a novel member of the RNA editing deaminase family in germinal center B cells
Journal ArticleDOI
“Destemming” Cancer Stem Cells
Richard P. Hill,Roberto Perris +1 more
TL;DR: Interest in cancer stem cells is currently high, arising from recent reports identifying cell surface markers that can be used to sort such cells from primary human tumors, but use of the term cancer stem cell may be misleading.
Journal ArticleDOI
Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype.
Marta B. Davidson,Yuki Katou,Andrea Keszthelyi,Tina L. Sing,Tian Xia,Jiongwen Ou,Jessica A. Vaisica,Neroshan Thevakumaran,Lisette Marjavaara,Chad L. Myers,Andrei Chabes,Katsuhiko Shirahige,Grant W. Brown +12 more
TL;DR: The data point to a vicious circle in which mutations in gatekeeper genes give rise to genomic instability during S phase, inducing expansion of the dNTP pool, which in turn results in high levels of spontaneous mutagenesis.
References
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Journal ArticleDOI
Prospective identification of tumorigenic breast cancer cells
Muhammad Al-Hajj,Max S. Wicha,Adalberto Benito-Hernandez,Sean J. Morrison,Sean J. Morrison,Michael F. Clarke +5 more
TL;DR: The ability to prospectively identify tumorigenic cancer cells will facilitate the elucidation of pathways that regulate their growth and survival and strategies designed to target this population may lead to more effective therapies.
Book
The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Identification of human brain tumour initiating cells
Sheila K. Singh,Cynthia Hawkins,Ian D. Clarke,Jeremy A. Squire,Jane Bayani,Takuichiro Hide,R. Mark Henkelman,Michael D. Cusimano,Peter B. Dirks +8 more
TL;DR: The development of a xenograft assay that identified human brain tumour initiating cells that initiate tumours in vivo gives strong support for the CSC hypothesis as the basis for many solid tumours, and establishes a previously unidentified cellular target for more effective cancer therapies.
Journal ArticleDOI
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
Dominique Bonnet,John E. Dick +1 more
TL;DR: It is demonstrated that the cell capable of initiating human AML in non-obese diabetic mice with severe combined immunodeficiency disease (NOD/SCID mice) — termed the SCID leukemia-initiating cell, or SL-IC — possesses the differentiate and proliferative capacities and the potential for self-renewal expected of a leukemic stem cell.