Open Access
Genetic background of extreme violent behavior
Jari Tiihonen,M-R Rautiainen,Hanna Ollila,Eila Repo-Tiihonen,Matti Virkkunen,Aarno Palotie,Olli Pietiläinen,Kati Kristiansson,Matti Joukamaa,Hannu Lauerma,Janna Saarela,Sasu Tyni,Heikki Vartiainen,Jussi Paananen,David Goldman,Tiina Paunio +15 more
Reads0
Chats0
TLDR
In this article, the authors found that both low monoamine metabolism and neuronal membrane dysfunction are plausible factors in the etiology of extreme criminal violent behavior, and imply that at least about 5-10% of all severe violent crime in Finland is attributable to the aforementioned MAOA and CDH13 genotypes.Abstract:
In developed countries, the majority of all violent crime is committed by a small group of antisocial recidivistic offenders, but no genes have been shown to contribute to recidivistic violent offending or severe violent behavior, such as homicide. Our results, from two independent cohorts of Finnish prisoners, revealed that a monoamine oxidase A (MAOA) low-activity genotype (contributing to low dopamine turnover rate) as well as the CDH13 gene (coding for neuronal membrane adhesion protein) are associated with extremely violent behavior (at least 10 committed homicides, attempted homicides or batteries). No substantial signal was observed for either MAOA or CDH13 among non-violent offenders, indicating that findings were specific for violent offending, and not largely attributable to substance abuse or antisocial personality disorder. These results indicate both low monoamine metabolism and neuronal membrane dysfunction as plausible factors in the etiology of extreme criminal violent behavior, and imply that at least about 5–10% of all severe violent crime in Finland is attributable to the aforementioned MAOA and CDH13 genotypes.read more
Citations
More filters
A population-specific HTR2B stop codon predisposes to severe impulsivity
Laura Bevilacqua,Stéphane Doly,Jaakko Kaprio,Jaakko Kaprio,Qiaoping Yuan,Roope Tikkanen,Tiina Paunio,Zhifeng Zhou,Juho Wedenoja,Juho Wedenoja,Luc Maroteaux,Silvina L. Diaz,Arnauld Belmer,Colin A. Hodgkinson,Liliana Dell'Osso,Jaana Suvisaari,Emil F. Coccaro,Richard J. Rose,Leena Peltonen,Matti Virkkunen,David Goldman +20 more
TL;DR: In this paper, a stop codon in HTR2B was identified that is common (minor allele frequency > 1%) but exclusive to Finnish people, which was associated with psychiatric diseases marked by impulsivity in both population and family-based analyses.
Journal ArticleDOI
The neurobiological basis of human aggression: a review on genetic and epigenetic mechanisms
TL;DR: It is hypothesized that from a genetic perspective, the aminergic systems are likely to regulate both reactive and proactive aggression, whereas the endocrine pathways seem to be more involved in regulation of reactive aggression through modulation of impulsivity.
Journal ArticleDOI
Genome-wide association studies of a broad spectrum of antisocial behavior
Jorim J. Tielbeek,Jorim J. Tielbeek,Jorim J. Tielbeek,Ada Johansson,Ada Johansson,Ada Johansson,Tinca J. C. Polderman,Marja-Riitta Rautiainen,Marja-Riitta Rautiainen,Marja-Riitta Rautiainen,Philip R. Jansen,Philip R. Jansen,Michelle Taylor,Xiaoran Tong,Qing Lu,Alexandra S. Burt,Henning Tiemeier,Essi Viding,Robert Plomin,Nicholas G. Martin,Andrew C. Heath,Pamela A. F. Madden,Grant W. Montgomery,Kevin M. Beaver,Kevin M. Beaver,Irwin D. Waldman,Joel Gelernter,Joel Gelernter,Henry R. Kranzler,Henry R. Kranzler,Lindsay A. Farrer,John R. B. Perry,Marcus R. Munafò,Devon LoParo,Tiina Paunio,Tiina Paunio,Tiina Paunio,Jari Tiihonen,Jari Tiihonen,Sabine E. Mous,Irene Pappa,Christiaan de Leeuw,Kyoko Watanabe,Anke R. Hammerschlag,Anke R. Hammerschlag,Jessica E. Salvatore,Fazil Aliev,Fazil Aliev,Tim B. Bigdeli,Danielle M. Dick,Stephen V. Faraone,Arne Popma,Sarah E. Medland,Danielle Posthuma +53 more
TL;DR: The Broad Antisocial Behavior Consortium entails the largest collaboration to date on the genetic architecture of ASB, and the first results suggest that ASB may be highly polygenic and has potential heterogeneous genetic effects across sex.
Journal ArticleDOI
Genetics of aggressive behavior: An overview
Kim Veroude,Yanli Zhang-James,Noèlia Fernàndez-Castillo,Mireille J. Bakker,Bru Cormand,Stephen V. Faraone,Stephen V. Faraone +6 more
TL;DR: This review sought to present the evidence for genetic underpinnings of aggression and to determine to what degree prior studies have examined phenotypes that fit into the RDoC framework.
Journal ArticleDOI
Cadherin-13, a risk gene for ADHD and comorbid disorders, impacts GABAergic function in hippocampus and cognition
Olga Rivero,Martijn Selten,S. Sich,Sandy Popp,L. Bacmeister,Elena Amendola,Moritz Negwer,Dirk Schubert,Florian Proft,Dominik P. Kiser,Angelika Schmitt,Cornelius Gross,Sharon M. Kolk,Tatyana Strekalova,D.L.A. van den Hove,Thérèse J. Resink,Nael Nadif Kasri,Klaus-Peter Lesch,Klaus-Peter Lesch +18 more
TL;DR: Results indicate that CDH13 is a negative regulator of inhibitory synapses in the hippocampus, and provide insights into howCDH13 dysfunction may contribute to the excitatory/inhibitory imbalance observed in neurodevelopmental disorders, such as ADHD and autism.
References
More filters
Journal ArticleDOI
Role of Genotype in the Cycle of Violence in Maltreated Children
Avshalom Caspi,Avshalom Caspi,Joseph L. McClay,Terrie E. Moffitt,Terrie E. Moffitt,Jonathan Mill,Judy Martin,Ian W. Craig,Alan Taylor,Richie Poulton +9 more
TL;DR: In this paper, a large sample of male children from birth to adulthood was studied to determine why some children who are maltreated grow up to develop antisocial behavior, whereas others do not.
Journal ArticleDOI
Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A
TL;DR: Analytical results indicate that isolated complete MAOA deficiency in this family is associated with a recognizable behavioral phenotype that includes disturbed regulation of impulsive aggression.
Journal ArticleDOI
Genetic influences in criminal convictions: evidence from an adoption cohort
TL;DR: The possibility that genetic factors are among the causes of criminal behavior was tested by comparing court convictions of 14,427 adoptees with those of their biological and adoptive parents, and there was no statistically significant correlation between adoptee and adoptive parent court convictions.
Journal ArticleDOI
Implications of Sex Differences in the Prevalences of Antisocial Personality, Alcoholism, and Criminality for Familial Transmission
TL;DR: Three multifactorial models of disease transmission in which the prevalences of a disease differ in men and women are described to demonstrate explicitly how such sex differences may be caused by genetic factors, home environment, sociocultural, or other nonfamilial factors.
Journal ArticleDOI
MAOA, childhood maltreatment and antisocial behavior: Meta-analysis of a gene-environment interaction
Amy L. Byrd,Stephen B. Manuck +1 more
TL;DR: A meta-analysis of studies testing the interaction of MAOA genotype and childhood adversities on antisocial outcomes in predominantly nonclinical samples found common regulatory variation in MAOA to moderate effects of childhood maltreatment on male antisocial behaviors, confirming a sentinel finding in research on gene-environment interaction.