Journal ArticleDOI
Genetic determinants of oxidative stress-mediated sensitization of drug-resistant cancer cells†
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TLDR
Whether ROS reduction in drug‐resistant cancer cells could be a general mechanism of drug resistance for most cancers with its specific drug, and whether elevation of ROS levels with the drug could beA valuable strategy for increasing drug efficacy in most cancers is discussed.Abstract:
Drug resistance in cancer is an overwhelming problem, because drug-resistant cancer cells are harder to kill with the same drug. The mechanism of drug resistance differs for various cancers based on the type of drug being used for its treatment. Most current drugs are shown to increase reactive oxygen species (ROS) in respective cancer cells that induces apoptosis, but continuous treatment with the same drug may reduce cellular ROS levels and may convert drug sensitive cancer cells into drug resistant cells. In addition, exogenous elevation of ROS in conjunction with drug resensitizes drug-resistant cancer cells. Thus, constant maintenance of higher ROS level in cancer cells may be a prerequisite for drug efficacy in certain type of cancer cells. Thus, modulation of ROS-mediated genetic pathway genes could be an efficient alternative to maintain higher ROS level in cancer cells for "combinational chemotherapy" with the drug. In this review, I discuss whether ROS reduction in drug-resistant cancer cells could be a general mechanism of drug resistance for most cancers with its specific drug, and whether elevation of ROS levels with the drug could be a valuable strategy for increasing drug efficacy in most cancers.read more
Citations
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Oxidative stress and lipid peroxidation products in cancer progression and therapy.
TL;DR: Recent advances in the studies of the relation between oxidative stress, lipid peroxidation products, and cancer progression are focused on, with particular attention to the pro-oxidant anticancer agents and the drug-resistant mechanisms, which could be modulated to obtain a better response to cancer therapy.
Journal ArticleDOI
Oxidative stress in apoptosis and cancer: an update.
TL;DR: New knowledge about recent tools that provide powerful antioxidant strategies, and designing methods to deliver to target cells, in the prevention and treatment of cancer are discussed.
Journal ArticleDOI
The Roles of ROS in Cancer Heterogeneity and Therapy
Paulo Luiz de Sá Júnior,Diana Aparecida Dias Câmara,Allan Saj Porcacchia,Pâmela Maria Moreira Fonseca,Salomão Dória Jorge,Rodrigo Pinheiro Araldi,Adilson Kleber Ferreira +6 more
TL;DR: What ROS are and how they are produced in normal and in cancer cells are reviewed while providing an argumentative discussion about their role in cancer pathophysiology.
Journal ArticleDOI
The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: oxidative stress and the seesaw of cell survival and death.
TL;DR: The role of sphingolipid rheostat and sphingosine-1-phosphate (S1P) signaling in cell proliferation, apoptosis, autophagy, and senescence was discussed in this article.
Journal ArticleDOI
Cancer drug resistance: redox resetting renders a way
TL;DR: Insight is provided into the role of ‘Redox Resetting’ on the emergence of drug resistance that may contribute to pharmacological modulation of resistance.
References
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Journal ArticleDOI
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
Journal ArticleDOI
Reactive oxygen species in cancer
Geou Yarh Liou,Peter Storz +1 more
TL;DR: The generation of ROS within tumour cells, their detoxification, their cellular effects, as well as the major signalling cascades they utilize are discussed, but also an outlook on their modulation in therapeutics is provided.
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Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
Frank Weinberg,Robert B. Hamanaka,William W. Wheaton,Samuel E. Weinberg,Joy Joseph,Marcos Lopez,Balaraman Kalyanaraman,Gökhan M. Mutlu,G. R. Scott Budinger,Navdeep S. Chandel +9 more
TL;DR: It is reported that the major function of glucose metabolism for Kras-induced anchorage-independent growth, a hallmark of transformed cells, is to support the pentose phosphate pathway.
Journal ArticleDOI
Oxidative Stress and Oxidative Damage in Carcinogenesis
TL;DR: Evidence demonstrates an association between a number of single nucleotide polymorphisms in oxidative DNA repair genes and antioxidant genes with human cancer susceptibility and the resultant altered gene expression patterns evoked by ROS contribute to the carcinogenesis process.
Journal ArticleDOI
Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
TL;DR: This Review assesses the association of GEFs and GAPs with cancer and their druggability for cancer therapeutics.