Genetic modifiers of beta-thalassemia.
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Cites background from "Genetic modifiers of beta-thalassem..."
...In addition, multiple modifying factors in several pathways involved in the pathophysiology of the disease have been identified (Thein 2005)....
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155 citations
Cites background from "Genetic modifiers of beta-thalassem..."
...…-globin genes may produce a more marked imbalance in globin chain production thus leading to a clinical picture of thalassemia intermedia even in simple heterozygotes for -thalassemia, who are otherwise generally clinically silent (Cao & Moi, 2002; Thein, 2005; Weatherall, 2001; Wong et al., 2004)....
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...On the other hand, triplication or quadruplication rearrangements of -globin genes may produce a more marked imbalance in globin chain production thus leading to a clinical picture of thalassemia intermedia even in simple heterozygotes for -thalassemia, who are otherwise generally clinically silent (Cao & Moi, 2002; Thein, 2005; Weatherall, 2001; Wong et al., 2004)....
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Cites background from "Genetic modifiers of beta-thalassem..."
...However, demographic events, such as migration and the consequent intermixing of populations, have contributed to the spread of Hb disorders worldwide [3,4]....
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