Journal ArticleDOI
Genetic polymorphism of metallothionein 2A and risk of laryngeal cancer in a Polish population.
Katarzyna Starska,Anna Krześlak,Ewa Forma,Jurek Olszewski,Iwona Lewy-Trenda,Ewa Osuch-Wójcikiewicz,Magdalena Bryś +6 more
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TLDR
The results of this study raise a possibility that a genetic variation of MT2A may be implicated in the etiology of laryngeal cancer in a Polish population.Abstract:
Metallothioneins are intracellular regulators of many biological mechanisms including differentiation, proliferation, angiogenesis and invasion, which are crucial processes in carcinogenesis. This study examines the association between three single-nucleotide polymorphisms at loci -5 A/G (rs28366003) and -209 A/G (rs1610216) in the core promoter region and at locus +838 C/G (rs10636) in 3'UTR region of the metallothionein 2A (MT2A) gene with squamous cell laryngeal cancer (SCLC) risk, as well as with tumor invasiveness according to tumor front grading (TFG). Genotyping was performed using the polymerase chain reaction-restriction fragment length polymorphism technique in 323 genetically unrelated individuals with SCLC and 418 randomly selected healthy volunteers. Only one SNP (rs28366003) was significantly related to laryngeal cancer in the study population. Compared with homozygous common allele carriers, heterozygous and homozygous for the G variant had significantly increased risk of SCLC [adjusted odds ratio (OR) = 2.90, 95 % confidence interval (CI) 1.53-5.21, p dominant 18 points) (OR = 3.76, 95 % CI 1.15-12.56, p = 0.03) and diffuse tumor growth (OR = 5.86, 95 % Cl 0.72-44.79, p = 0.08). The results of this study raise a possibility that a genetic variation of MT2A may be implicated in the etiology of laryngeal cancer in a Polish population.read more
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Journal ArticleDOI
Mammalian Metallothionein-2A and Oxidative Stress
TL;DR: A deeper understanding of the functional, biochemical and molecular characteristics of MT2A would be identified, in order to bring new opportunities for oxidative stress therapy.
Journal ArticleDOI
An insight into the complex roles of metallothioneins in malignant diseases with emphasis on (sub)isoforms/isoforms and epigenetics phenomena.
Sona Krizkova,Marta Kepinska,Gabriella Emri,Tomas Eckschlager,Marie Stiborová,Petra Pokorná,Zbynek Heger,Vojtech Adam,Vojtech Adam +8 more
TL;DR: Methods for analysis of MTs at (sub)isoforms levels, their expression in single tumour diseases and strategies how this knowledge can be utilized in anticancer therapy are reviewed.
Journal ArticleDOI
Genetic polymorphisms (rs10636 and rs28366003) in metallothionein 2A increase breast cancer risk in Chinese Han population.
Di Liu,Meng Wang,Tian Tian,Xi-Jing Wang,Huafeng Kang,Tianbo Jin,Shuqun Zhang,Hai-Tao Guan,Pengtao Yang,Kang Liu,Xinghan Liu,Peng Xu,Yi Zheng,Zhijun Dai +13 more
TL;DR: The results indicated that the rs10636 and rs28366003 polymorphisms in MT2A increased BC risk in Northwest Chinese Han population.
Journal ArticleDOI
Genetic variation in metallothionein and metal-regulatory transcription factor 1 in relation to urinary cadmium, copper, and zinc
Scott V. Adams,Brian Barrick,Emily P. Christopher,Martin M. Shafer,Karen W. Makar,Xiaoling Song,Johanna W. Lampe,Hugo Vilchis,April L. Ulery,Polly A. Newcomb +9 more
TL;DR: The results suggest that genetic variation in the MT gene region and MTF1 influences urinary Cd, Cu, and Zn excretion.
Journal ArticleDOI
Metallothionein 2A core promoter region genetic polymorphism and its impact on the risk, tumor behavior, and recurrences of sinonasal inverted papilloma (Schneiderian papilloma)
Katarzyna Starska,Magdalena Bryś,Ewa Forma,Jurek Olszewski,Piotr Pietkiewicz,Iwona Lewy-Trenda,Olga Stasikowska-Kanicka,Marian Danilewicz,Anna Krześlak +8 more
TL;DR: The findings suggest that MT2A gene variation rs28366003 may be implicated in the etiology of sinonasal inverted papilloma in a Polish population.
References
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Journal ArticleDOI
The American Joint Committee on Cancer: the 7th Edition of the AJCC Cancer Staging Manual and the Future of TNM
TL;DR: A marked increase in the use of international datasets for more highly evidenced-based changes in staging, and the enhanced use of nonanatomic prognostic factors in defining the stage grouping are notable.
Journal ArticleDOI
A Review of Metallothionein Isoforms and their Role in Pathophysiology
N Thirumoorthy,A Shyam Sunder,KT Manisenthil Kumar,M Senthil kumar,Gnk Ganesh,Malay Chatterjee +5 more
TL;DR: This review's main objective is to explore the capability to specifically manipulate MT levels in cells and in animals to provide answers regarding how MT could impact those complex disease scenarios.
Journal ArticleDOI
Mammalian metallothioneins: properties and functions
Petr Babula,Petr Babula,Michal Masarik,Vojtech Adam,Vojtech Adam,Tomas Eckschlager,Marie Stiborová,Libuše Trnková,Helena Skutkova,Ivo Provaznik,Jaromir Hubalek,Jaromir Hubalek,Jaromir Hubalek,René Kizek,René Kizek +14 more
TL;DR: In this review, the connection between zinc(II) ions, reactive oxygen species, heavy metal ions and metallothioneins is demonstrated with respect to effect of these proteins on cell proliferation and a possible negative role in resistance to heavy metal-based and non-heavy metal- based drugs.
Journal ArticleDOI
The role of metallothionein in oncogenesis and cancer prognosis.
TL;DR: The role of metallothionein+II both as a prognostic marker for survival and therapy response, as well as for the hypothesized role of MT-I+II as causal oncogenes are discussed.
Journal ArticleDOI
Metallothionein polymorphisms in pathological processes
Martina Raudenská,Martina Raudenská,Jaromír Gumulec,Jaromír Gumulec,Ondrej Podlaha,Markéta Sztalmachová,Markéta Sztalmachová,Petr Babula,Tomas Eckschlager,Vojtech Adam,Vojtech Adam,René Kizek,René Kizek,Michal Masarik,Michal Masarik +14 more
TL;DR: This review summarizes all evidence regarding MT polymorphisms of major human MTs, their relation to pathological processes, and outlines specific applications of MTs as a set of genetic markers for certain pathologies.
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