Journal Article•
Genetic polymorphisms of DNA repair genes in patients with hepatocellular carcinoma
TL;DR: Genetic polymorphisms of DNA repair genes are not associated with hepatocarcinogenesis and frequency of wild-type allele of X-ray repair cross complementing group 1(XRCC1) Arg399Gln is higher in case group.
Abstract: Objective To investigate the relationship between genetic polymorphisms of DNA repair genes and hepatocellular carcinomaMethods Genetic polymorphisms of DNA repair genes had been identified in 150 pateients with hepatocellular carcinoma(case group) and 150 healthy individuals(control group) by PCR-RFLPResults Compared with control group,frequency of wild-type allele of X-ray repair cross complementing group 1(XRCC1) Arg399Gln is higher in case groupNo significant difference of urinary 8-hydroxy-2-deoxyguanosine(8-OHdG) levels among different polymorphism genotypes in XRCC1 Arg194Tr,Arg280His,Arg399Gln and human 8-oxoguanine DNA glycosylase 1(hOGG1) Ser326CysConclusion Genetic polymorphisms of DNA repair genes are not associated with hepatocarcinogenesis
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TL;DR: There is limited evidence to support that the hOGG1 Ser326Cys polymorphism is associated with HCC risk among East Asians, and well-designed and large-sized studies are required to determine this relationship.
Abstract: Background
The hOGG1 gene encodes a DNA glycosylase enzyme responsible for DNA repair. The Ser326Cys polymorphism in this gene may influence its repair ability and thus plays a role in carcinogenesis. Several case-control studies have been conducted on this polymorphism and its relationship with the risk of hepatocellular carcinoma (HCC) among East Asians. However, their results are inconsistent.
Methods
We performed a meta-analysis of published case-control studies assessing the association of the hOGG1 Ser326Cys polymorphism with HCC risk among East Asians. PubMed, EMBASE, SCI, BIOSIS, CNKI and WanFang databases were searched. A random-effect model was used to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs). Analyses were conducted for additive, dominant and recessive genetic models.
Results
Eight studies were identified involving 2369 cases and 2442 controls assessing the association of the hOGG1 Ser326Cys polymorphism with HCC risk among East Asians. Applying a dominant genetic model, only in the Chinese population, the Cys allele was significantly associated with increased risk of HCC (OR 1.56, 95% CI 1.12–2.17). However, two studies influenced this finding according to sensitivity analysis. Furthermore, considerable heterogeneity and bias existed among Chinese studies.
Conclusion
There is limited evidence to support that the hOGG1 Ser326Cys polymorphism is associated with HCC risk among East Asians. Well-designed and large-sized studies are required to determine this relationship.
22 citations
Cites background from "Genetic polymorphisms of DNA repair..."
...Eligible Studies There were 8 studies identified on the hOGG1 Ser326Cys polymorphism and HCC susceptibility (Figure 1) [9,10,11,12,13,14,15,16]....
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...In the past years, several studies have investigated the association of the hOGG1 Ser326Cys polymorphism with HCC risk among East Asians [9,10,11,12,13,14,15,16]....
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...Conclusion: There is limited evidence to support that the hOGG1 Ser326Cys polymorphism is associated with HCC risk among East Asians....
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...However, the others found no association [9,10,11,12,14,15]....
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...6 studied Chinese population [9,11,12,13,14,16], 1 studied Japanese population [10], and 1 studied Korean population [15]....
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TL;DR: The present meta-analysis concluded that the G allele of Ser326Cys polymorphism of the hOGG1 gene was associated with an increased risk of cancer and suggested that the hogG1 polymorphism may be a candidate marker of cancer.
Abstract: // Sang Wook Kang 2,* , Su Kang Kim 1,* , Hae Jeong Park 1 , Joo-Ho Chung 1 and Ju Yeon Ban 2 1 Kohwang Medical Institute, School of Medicine, Kyung Hee University, Seoul, Republic of Korea 2 Department of Dental Pharmacology, School of Dentistry, Dankook University, Cheonan, Republic of Korea * First two authors equally contributed Correspondence to: Ju Yeon Ban, email: // Keywords : hOGG1, polymorphism, Ser326Cys, cancer, meta-analysis Received : September 27, 2016 Accepted : March 03, 2017 Published : March 15, 2017 Abstract Genetic polymorphism of human 8-oxoguanine glycosylase 1 ( hOGG1 ) has been reported to have a relationship with the risk of the development of various cancers. Many studies have described the influence of Ser326Cys polymorphism of the hOGG1 gene on cancer susceptibility. However, the results have remained inconclusive and controversial. Therefore, we performed a meta-analysis to more precisely determine the relationship between the hOGG1 polymorphism and the development of cancer. Electronic databases including PubMed, Embase, Google Scholar, and the Korean Studies Information Service System (KISS) were searched. The odds ratio (OR), 95% confidence interval (CI), and p value were calculated to assess the strength of the association with the risk of cancer using Comprehensive Meta-analysis software (Corporation, NJ, USA). The 127 studies including 38,757 cancer patients and 50,177 control subjects were analyzed for the meta-analysis. Our meta-analysis revealed that G allele of Ser326Cys polymorphism of the hOGG1 gene statistically increased the susceptibility of cancer (all population, OR = 1.092, 95% CI = 1.051-1.134, p < 0.001; in Asian, OR = 1.095, 95% CI = 1.048-1.145, p < 0.001; in Caucasian, OR = 1.097, 95% CI = 1.033-1.179, p = 0.002). Also, other genotype models showed significant association with cancer ( p < 0.05, respectively). The present meta-analysis concluded that the G allele was associated with an increased risk of cancer. It suggested that the hOGG1 polymorphism may be a candidate marker of cancer.
17 citations
Cites background from "Genetic polymorphisms of DNA repair..."
...Finally, a total of 127 genetic studies about the hOGG1 polymorphism and cancer were analyzed for meta-analysis (Supplementary Table 1) [5, 10-143]....
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TL;DR: In the Chinese Han population, the XRCC1 Arg399Gln gene polymorphism is associated with an increased hepatocellular carcinoma risk.
Abstract: Purpose: Numerous studies have evaluated the association between XRCC1 Arg399Gln gene polymorphism and hepatocellular carcinoma risk in the Chinese Han population. However, the results have been inconsistent. We therefore here examined whether the XRCC1 Arg399Gln gene polymorphism confers hepatocellular carcinoma risk by conducting a meta-analysis. Methods: PubMed, Google scholar and China National Knowledge Infrastructure databases were searched for eligible articles in English and Chinese that were published before April 2012. Results: 6 studies involving 1,246 patients with hepatocellular carcinoma and 1,953 controls were included. The association between XRCC1 Arg399Gln gene polymorphism and hepatocellular carcinoma in the Chinese Han population was significant under GG vs AA (OR = 1.48, 95% CI = 1.13 to 1.94). Limiting the analysis to the studies with controls in the Hardy-Weinberg equilibrium, the results were persistent and robust. Conclusions: In the Chinese Han population, the XRCC1 Arg399Gln gene polymorphism is associated with an increased hepatocellular carcinoma risk.
14 citations
TL;DR: The XRCC1 Arg194Trp gene polymorphism may not be a risk or protective factor for HCC, and a meta-analysis of previously published studies showed no significant association between it and the risk of HCC.
Abstract: The arginine194tryptophan (Arg194Trp) polymorphism in the X-ray repair cross-complementing group 1 (XRCC1) gene has been reported to be associated with hepatocellular carcinoma (HCC), however, the results from previous studies are conflicting. The present study aimed to investigate the association between the XRCC1 Arg194Trp polymorphism and the risk of HCC, using a meta-analysis of previously published studies. PubMed (http://www.ncbi.nlm.nih.gov/pubmed/), Google Scholar (http://scholar.google.co.uk/) and the China National Knowledge Infrastructure databases (http://www.cnki.net/) were systematically searched to identify relevant studies published prior to October 2013. A meta-analysis was performed to examine the association between the Arg194Trp gene polymorphism and the susceptibility to HCC. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. The meta-analysis consisted of six case-control studies that included 1,451 HCC cases and 1,398 healthy controls. Meta-analysis results based on all the studies showed no significant association between the XRCC1 Arg194Trp gene polymorphism and the risk of HCC (Trp/Trp vs. Arg/Arg: OR, 1.17; 95% CI, 0.89–1.55; Trp/Trp vs. Arg/Trp: OR, 0.94; 95% CI, 0.59–1.51; dominant model: OR, 0.97; 95% CI, 0.63–1.49; recessive model: OR, 1.22; 95% CI, 0.89–1.67). In the subgroup analysis, three studies with sample sizes of >300 produced similar results that indicated that the Arg194Trp gene polymorphism had no association with an increased or decreased risk of HCC. The pooled ORs were not markedly different following the exclusion of two studies deviating from the Hardy-Weinberg equilibrium in the control group, which indicated the reliability of the meta-analysis results. In conclusion, the XRCC1 Arg194Trp polymorphism may not be a risk or protective factor for HCC. Further large and well-designed studies are required to confirm these results.
14 citations
TL;DR: The results suggest that XRCC1 Arg399Gln polymorphism may increase HCC risk especially among Asians, however, XR CC1Arg399GlN polymorphism might act as a protective role against HCC among Caucasians.
Abstract: Background: Various studies have evaluated the relationship between X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism and hepatocellular carcinoma (HCC) risk, but the conclusions have been inconsistent and underpowered. The purpose of this updated meta-analysis was to examine whether XRCC1 Arg399Gln polymorphism confers susceptibility to HCC. Methods: Eligible studies extracted from PubMed, Embase, Cochrane Library, VIP (chinese) and CNKI (chinese) up to November 2013 were included in the study. Pooled odds ratio (OR) together with their 95% confidence interval (CI) were estimated to evaluate XRCC1 Arg399Gln polymorphism and HCC risk. Results: Finally, 21 studies with 4,170 cases and 5,030 controls were involved in our meta-analysis. The results demonstrated that there was significant association between Arg399Gln polymorphism and HCC risk under two contrast models in overall populations (AG vs GG: OR=1.265, 95%CI=1.036-1.545, p=0.021; AA+AG vs GG: OR=1.240, 95%CI=1.021-1.506, p=0.030). In subgroup analyses, significant association was found in Asians (A vs G: OR=1.175, 95%CI=1.013-1.362, p=0.033; AG vs GG: OR=1.317, 95%CI=1.070-1.622, p=0.009; AA+AG vs GG: OR=1.289, 95%CI=1.055-1.575, p=0.013) and Caucasians (A vs G: OR=0.591, 95%CI=0.361-0.966, p=0.036; AA+AG vs GG: OR=0.468, 95%CI=0.234-0.934, p=0.031). Conclusions: The results suggest that XRCC1 Arg399Gln polymorphism may increase HCC risk especially among Asians. However, XRCC1 Arg399Gln polymorphism might act as a protective role against HCC among Caucasians.
13 citations