Genome Engineering With Zinc-Finger Nucleases
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"Genome Engineering With Zinc-Finger..." refers background in this paper
...Procedures for gene replacement in baker’s yeast, Saccharomyces cerevisiae, have been available for several decades (Scherer and Davis 1979; Rothstein 1983)....
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2,656 citations
"Genome Engineering With Zinc-Finger..." refers background in this paper
...The TAL effector domain, found in some Xanthomonas proteins involved in manipulating host gene expression, is composed of modules of 34 amino acids, each of which contacts a single base pair (Boch et al. 2009; Moscou and Bogdanove 2009)....
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2,172 citations
"Genome Engineering With Zinc-Finger..." refers background in this paper
...Fusions of TAL domains to the FokI nuclease domain (TALNs or TALENs) direct cleavage to specific sites both in vitro and in vivo (Christian et al. 2010; Li et al. 2011; Miller et al. 2011)....
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2,074 citations
"Genome Engineering With Zinc-Finger..." refers background or methods in this paper
...The current clinical trial, involving ZFN knockout of the CCR5 gene, represents the first of many possible therapeutic applications to humans (Urnov et al. 2010)....
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...The ZFNs employed in a current clinical trial have been selected, refined, and tested extensively (Perez et al. 2008; Urnov et al. 2010)....
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2,069 citations