Genome instability: a mechanistic view of its causes and consequences
Citations
3,146 citations
Cites background from "Genome instability: a mechanistic v..."
...In addition, cells are exposed to exogenous and endogenous insults that can induce small mutations as well as gross chromosomal rearrangement...
[...]
934 citations
866 citations
Additional excerpts
...The observation of a selective pressure in somatic cells for the inactivation of DDR genes during cancer progression is consistent with known cancer predisposition in patients and mouse models that carry germline mutations which impair DDR gene function...
[...]
825 citations
Cites background from "Genome instability: a mechanistic v..."
...Yeast THO and THSC/TREX-2 R loop-forming mutants show a transcription-associated hyperrecombination phenotype and elevated chromosome and plasmid loss (reviewed in Aguilera and Gómez-González, 2008)....
[...]
...Similarly, DNA repeats with the potential to form hairpins are a strong source of DNA breaks and DNA polymerase stalling (reviewed in Aguilera and Gómez-González, 2008; Mirkin and Mirkin, 2007; Pearson et al., 2005)....
[...]
760 citations
Cites background from "Genome instability: a mechanistic v..."
...Genetic mutations that affect enzymes involved in replication result in an accumulation of DNA intermediates that trigger recombination and genome instabilit...
[...]
References
5,297 citations
5,209 citations
"Genome instability: a mechanistic v..." refers background in this paper
...Key to the understanding of TAR and TAM is the fact that ssDNA is chemically more unstable than dsDN...
[...]
5,132 citations
1,909 citations
1,829 citations