Genome maintenance mechanisms for preventing cancer
Citations
5,650 citations
Cites background from "Genome maintenance mechanisms for p..."
...Poly(ADP-ribose) polymerase (PARP) is an enzyme involved in base excision repair, a key pathway in the repair of DNA single-strand break...
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4,871 citations
4,215 citations
Cites background from "Genome maintenance mechanisms for p..."
...Poly ADP-ribose polymerase (PARP) enzymes are critical for appropriate processing and repair of DNA breaks (8)....
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3,332 citations
2,579 citations
Cites background from "Genome maintenance mechanisms for p..."
...Sequence alterations in DNA arise from spontaneous chemical changes in DNA constituents, replication errors and damage inflicted on the DN...
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References
8,665 citations
"Genome maintenance mechanisms for p..." refers background in this paper
...Evolution has invested significantly in reducing the price of its own metabolism by implementing an intricate antioxidant defence system composed of enzymatic (superoxide dismutase, catalase, glutathione peroxidase and peroxyredoxins) and low-molecular-mass scavengers (such as glutathione...
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"Genome maintenance mechanisms for p..." refers background in this paper
...Spontaneous or induced deamination of cytosine, adenine, guanine or 5-methylcytosine converts these bases to the miscoding uracil, hypoxanthine, xanthine and thymine, respectivel...
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3,230 citations
"Genome maintenance mechanisms for p..." refers background in this paper
...The cell-cycle machinery somehow senses genome injury and arrests at specific checkpoints in G1, S, G2 and M to allow repair of lesions before they are converted into permanent mutations (reviewed in ref...
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2,762 citations
"Genome maintenance mechanisms for p..." refers background in this paper
...However, in many human cells and tissues telomerase activity is low or absen...
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