Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes
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"Genome-Wide Association Identifies ..." refers background in this paper
...To clarify potential mechanisms, the top nine signals (ARAP1, two at MADD, PCSK1, TCF7L2, VPS13C/C2CD4A/B, SLC30A8, LARP6, and SGSM2) were also examined in relation to other glucometabolic traits (fasting and 2-h postload glucose and insulin, homeostasis model assessment estimates of b-cell function [HOMA-B] and insulin resistance [HOMA-IR] [28], glycated hemoglobin [A1C], T2D, and BMI [Table 3])....
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"Genome-Wide Association Identifies ..." refers methods in this paper
...We detected no significant associations for 2-h postload insulin or insulin sensitivity as estimated by the Matsuda index (31) (Table 3)....
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"Genome-Wide Association Identifies ..." refers methods in this paper
...The inverse-variance fixed effects meta-analysis method was used to evaluate the pooled regression estimates for additively coded SNPs using METAL (24)....
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"Genome-Wide Association Identifies ..." refers methods in this paper
...Genome-wide association inflation coefficients were estimated for each discovery cohort using the genomic control (GC) method (23) and applied subsequently to each individual SNP association test statistics to correct for cryptic relatedness....
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