Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention.
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"Genomic Risk Prediction of Coronary..." refers background or methods in this paper
...We utilized a metaanalytic strategy to construct a GRS for CAD (metaGRS) that captures the totality of information from the largest previous genome-wide association studies, and then investigated the external performance of this metaGRS in stratifying CAD risk in >480,000 individuals from the UK Biobank (UKB) (15)....
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...Details of the design of the UKB have been reported previously (15)....
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2,838 citations
"Genomic Risk Prediction of Coronary..." refers methods in this paper
...Sing T, Sander O, Beerenwinkel N, Lengauer T. ROCR: visualizing classifier performance in R. Bioinformatics 2005;21:3940–1....
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...The precision-recall curves (equivalent to the positivepredictive-value vs sensitivity curve) were computed in the R package “ROCR” (20), and the area under the curve was computed using numerical integration....
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