Genomics and Traditional Indian Ayurvedic Medicine
01 Jan 2016-pp 271-292
TL;DR: Ayurgenomics is proposed as a novel approach for integration of Ayurveda into current medical practice to address the variability in therapeutic outcome as well as evolve preventive measures in health and disease.
Abstract: In the present times need is being felt for a change in paradigm from the current practice of modern medicine. This is not only to meet the challenges in diagnosis and treatment of chronic and complex diseases but also to address the variability in therapeutic outcome as well as evolve preventive measures in health and disease. The advent of genomics has provided a tremendous impetus to this area. However, there are a number of gaps before this is realized. Ayurveda, the ancient Indian system of predictive and personalized medicine still holds contemporary in the current era of P4 (predictive, preventive, personalized, and participatory) medicine and also has a promotive component. Ayurveda has documented methods for maintenance of health and personalized management of diseases. It is also widely practiced in most Indian communities despite sociocultural variations and many aspects for preventive health are also integrated into Indian traditional living. Despite this a large number of challenges exist in getting this system to mainstream and for its global acceptability. This review highlights some of these aspects and also proposes Ayurgenomics as a novel approach for integration of Ayurveda into current medical practice.
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Journal Article•
TL;DR: Why interactome networks are important to consider in biology, how they can be mapped and integrated with each other, what global properties are starting to emerge from interactome network models, and how these properties may relate to human disease are detailed.
Abstract: Complex biological systems and cellular networks may underlie most genotype to phenotype relationships. Here, we review basic concepts in network biology, discussing different types of interactome networks and the insights that can come from analyzing them. We elaborate on why interactome networks are important to consider in biology, how they can be mapped and integrated with each other, what global properties are starting to emerge from interactome network models, and how these properties may relate to human disease.
1,323 citations
TL;DR: The development of Ayurgenomics could greatly enrich P4 medicine by providing a clear theoretical understanding of the whole patient and a practical application of ancient and modern preventative and therapeutic practices to improve mental and physical health.
Abstract: Within the disciplines of modern medicine, P4 medicine is emerging as a new field which focuses on the whole patient. The development of Ayurgenomics could greatly enrich P4 medicine by providing a clear theoretical understanding of the whole patient and a practical application of ancient and modern preventative and therapeutic practices to improve mental and physical health. One of the most difficult challenges today is understanding the ancient concepts of Ayurveda in terms of modern science. To date, a number of researchers have attempted this task, of which one of the most successful outcomes is the creation of the new field of Ayurgenomics. Ayurgenomics integrates concepts in Ayurveda, such as Prakriti, with modern genetics research. It correlates the combination of three doshas, Vata, Pitta and Kapha, with the expression of specific genes and physiological characteristics. It also helps to interpret Ayurveda as an ancient science of epigenetics which assesses the current state of the doshas, and uses specific personalized diet and lifestyle recommendations to improve a patient's health. This review provides a current update of this emerging field.
9 citations
Book Chapter•
01 Mar 2010TL;DR: The list of compounds derived from such knowledge is very long indeed and includes morphine, codeine, and aspirin to name just a few but also drugs licensed relatively recently like galanthamine and artemisinine as mentioned in this paper.
Abstract: Drug discovery and development (very often unknowingly) is based on traditional and local knowledge about a species’ medical use or toxicological effects (both desired and undesired effects). The list of compounds ultimately derived from such knowledge is very long indeed and includes morphine, codeine, and aspirin to name just a few but also drugs licensed relatively recently like galanthamine and artemisinine. Here I review this link and – using examples of new drugs currently under development preclinically or in clinical trials – discuss how such new drugs have been ‘discovered’, or more precisely developed into a clinically used medication.
3 citations
References
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TL;DR: Experimental and analytical approaches relating to exome sequencing have established a rich framework for discovering the genes underlying unsolved Mendelian disorders and set the stage for applying exome and whole-genome sequencing to facilitate clinical diagnosis and personalized disease-risk profiling.
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TL;DR: The distribution of types of mutation in mendelian disease genes argues for serious consideration of the early application of a genomic-scale sequence-based approach to association studies and against complete reliance on a positional cloning approach based on a map of anonymous single nucleotide polymorphism haplotypes.
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1,489 citations
TL;DR: In this paper, the authors discuss different types of interactome networks and the insights that can come from analyzing them, including how they can be mapped and integrated with each other, what global properties are starting to emerge from interactome network models, and how these properties may relate to human disease.
1,398 citations