Journal ArticleDOI
Genotoxicity studies of the food additive ester gum
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TLDR
Although EG was weakly clastogenic and could induce a marginal increase in sister chromatid exchange frequencies, it was not a potential health hazard at the doses tested.About:
This article is published in Food and Chemical Toxicology.The article was published on 1992-07-01. It has received 4 citations till now. The article focuses on the topics: Sister chromatid exchange & Genotoxicity.read more
Citations
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In vivo cytogenetic studies on mice exposed to acesulfame-K--a non-nutritive sweetener.
Anita Mukherjee,J. Chakrabarti +1 more
TL;DR: Acesulfame-K, a sweetening agent, was evaluated in vivo for its genotoxic and clastogenic potentials and should be used with caution.
Journal ArticleDOI
Contact allergy to ester gums in cosmetics.
TL;DR: This booklet contains information on how to identify and treat contact allergy, as well as practical applications for cosmetics and hair-removal strips.
Journal ArticleDOI
Re-evaluation of glycerol esters of wood rosin (E 445) as a food additive.
Maged Younes,Peter Aggett,Fernando Aguilar,Riccardo Crebelli,Metka Filipič,María José Frutos,Pierre Galtier,David Michael Gott,Ursula Gundert-Remy,Gunter G. C. Kuhnle,Claude Lambré,Jean-Charles Leblanc,Inger Therese Lillegaard,Peter Moldeus,Alicja Mortensen,Agneta Oskarsson,Ivan Stankovic,Ine Waalkens-Berendsen,Rudolf Antonius Woutersen,Matthew Wright,Leon Briemer,Mosesso Pasquale,Anna Christodoulidou,Zsuzsanna Horvath,Federica Lodi,Alexandra Tard,Birgit Dusemund +26 more
TL;DR: The Panel concluded that the mean and the high exposure levels (P95) of the brand‐loyal refined exposure scenario did not exceed the temporary ADI in any of the population groups from the use of GEWR (E 445) as a food additive at the reported use levels.
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Evaluation the Incidence of Genotoxic Effects of Artificial Food Favoring Additives in Bone Marrow Cells and Spleen Cells in Mice
Ali F. Hassan,Nibras H. Jasem +1 more
TL;DR: It was found that artificial food flavoring additive at concentration show not significant increase in total chromosomal aberration in both bone marrow cells and spleen cells when compare to negative control, meanwhile at concentration 150% it causes a significant increase when compareto negative control.
References
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Journal ArticleDOI
New Giemsa method for the differential staining of sister chromatids
Paul Perry,Sheldon Wolff +1 more
TL;DR: If human lymphocytes1 or Chinese hamster2 cells are treated with the base analogue 5-bromodeoxyuridine in the latter part of the S period, Giemsa stained chromosomes exhibit a pattern of condensed and extended segments along their length, allowing the identification of the two chromatids, and the observation of sister chromatid exchanges (SCEs) without recourse to autoradiography.
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Chromosome aberrations and sister chromatid exchanges in chinese hamster ovary cells: Evaluations of 108 chemicals
Sheila M. Galloway,M. J. Armstrong,C. Reuben,S. Colman,B. M. Brown,C. Cannon,A. D. Bloom,F. Nakamura,M. Ahmed,S. Duk,J. Rimpo,Barry H. Margolin,Michael A. Resnick,Beth Anderson,Errol Zeiger +14 more
TL;DR: Results from the testing of 108 coded chemicals in Chinese hamster ovary cells for the induction of chromosome aberrations and sister chromatid exchanges (SCEs) are presented.
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Statistical analyses for in vitro cytogenetic assays using Chinese hamster ovary cells
B. H. Margolin,Michael A. Resnick,J. Y. Rimpo,P. Archer,Sheila M. Galloway,A. D. Bloom,Errol Zeiger +6 more
TL;DR: In this paper, a trend test for evidence of a dose response is proposed for such SCE data, where the percent of cells with chromosome aberrations is the response of interest, and Monte Carlo methods are used to show that the trend test is more sensitive than four other statistical procedures considered for the analysis of Poisson-distributed SCE.
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Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3-butadiene.
TL;DR: The most sensitive measure of cytotoxic damage was AGT (significant at 62.5 ppm), followed by %PCE ( significant at 625 ppm), and then by MI (significant by trend test only), while the degree of concordance among the various indicators of genotoxic and cytot toxic damage ranged from a very good correlation to the lack of a significant correlation.
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Improved sister-chromatid differentiation using paraffin-coated bromodeoxyuridine tablets in mice
TL;DR: A quick and easy method for partially coating 5-bromo-2′-deoxyuridine tablets with paraffin before they were subcutaneously implanted in mice increased availability of the chemical from 8 to more than 24 h and significantly reduced the baseline level of sister-chromatid exchanges.