Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
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...A complete assessment of the geographic variability observed across 20 world regions is provided elsewhere.(4) This paper reviews the sources and methods used in compiling cancer incidence and mortality estimates for 2018 in 185 countries or territories worldwide....
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...There were an estimated 572,034 cases of esophageal cancer in 2018.([1]) The most common histological subtypes of esophageal...
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...Following the significant effectiveness of trastuzumab for preventing recurrences and death from ERBB2+ breast cancer, subsequent investigations have focused on (1) decreasing the number of accompanying chemotherapy agents in lower-risk patients and (2) adding novel agents in higher-risk patients....
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...58 Contraindications to conservative surgery include (1) the presence of diffuse suspicious microcalcifications on breast imaging; (2) positive pathologic margins after lumpectomy; (3) disease that cannot be addressed by excision of a single breast tissue region with satisfactory cosmetic result, except in highly select patients; (4) certain collagen-vascular diseases, such as scleroderma; and (5) prior radiotherapy to the involved breast....
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