Global cancer statistics
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TLDR
A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.Abstract:
The global burden of cancer continues to increase largely because of the aging and growth of the world population alongside an increasing adoption of cancer-causing behaviors, particularly smoking, in economically developing countries. Based on the GLOBOCAN 2008 estimates, about 12.7 million cancer cases and 7.6 million cancer deaths are estimated to have occurred in 2008; of these, 56% of the cases and 64% of the deaths occurred in the economically developing world. Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females, accounting for 23% of the total cancer cases and 14% of the cancer deaths. Lung cancer is the leading cancer site in males, comprising 17% of the total new cancer cases and 23% of the total cancer deaths. Breast cancer is now also the leading cause of cancer death among females in economically developing countries, a shift from the previous decade during which the most common cause of cancer death was cervical cancer. Further, the mortality burden for lung cancer among females in developing countries is as high as the burden for cervical cancer, with each accounting for 11% of the total female cancer deaths. Although overall cancer incidence rates in the developing world are half those seen in the developed world in both sexes, the overall cancer mortality rates are generally similar. Cancer survival tends to be poorer in developing countries, most likely because of a combination of a late stage at diagnosis and limited access to timely and standard treatment. A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination (for liver and cervical cancers), and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake. Clinicians, public health professionals, and policy makers can play an active role in accelerating the application of such interventions globally.read more
Citations
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Journal ArticleDOI
JMJD2A contributes to breast cancer progression through transcriptional repression of the tumor suppressor ARHI
Liliang Li,Aimin Xue,Bei-Xu Li,Yiwen Shen,Yuhua Li,Chengliang Luo,Mingchang Zhang,Jieqing Jiang,Zu-De Xu,Jianhui Xie,Ziqin Zhao +10 more
TL;DR: It is reported that Jumonji domain containing 2A (JMJD2A) could promote breast cancer progression through transcriptional repression of the tumor suppressor aplasia Ras homolog member I (ARHI).
Journal ArticleDOI
Association of candidate genetic variations with gastric cardia adenocarcinoma in Chinese population: a multiple interaction analysis.
Li Liu,Chen Wu,Ying Wang,Rong Zhong,Feng Wang,Xuemei Zhang,Shengyu Duan,Jiao Lou,Dianke Yu,Wen Tan,Jing Yuan,Tangchun Wu,Shaofa Nie,Xiaoping Miao,Dongxin Lin +14 more
TL;DR: It is suggested that MMP-2 C-1306T polymorphism is an important risk factor for GCA and the multifactor interactions among polymorphisms in M MP-2, FASL and FAS play more important role in the development of GCA.
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Garcinol inhibits tumour cell proliferation, angiogenesis, cell cycle progression and induces apoptosis via NF-κB inhibition in oral cancer.
Sadhna Aggarwal,Satya N. Das +1 more
TL;DR: It appears that garcinol exerts anti-proliferative, pro-apoptotic, cell-cycle regulatory and anti-angiogenic effects on oral cancer cells through inhibition of NF-κB and COX-2.
Journal Article
Delay in the Diagnosis and Treatment of Oral Cancer
TL;DR: Accuracy in recording the files and training the patients were recognized to be the most imperative factors to continue the treatment successfully to enhance the survival rate of the patients.
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Variation in causes of death in patients with non-small cell lung cancer according to stage and time since diagnosis
Maryska L.G. Janssen-Heijnen,F N van Erning,Dirk De Ruysscher,J.W.W. Coebergh,Harry J.M. Groen +4 more
TL;DR: With time, the relative contribution of cardiovascular and COPD causes of death increased, although the absolute contribution of lung cancer remained high in non-metastatic NSCLC, therefore, managing morbidity of these diseases remains relevant.
References
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