Global epidemiology of nonalcoholic fatty liver disease—Meta‐analytic assessment of prevalence, incidence, and outcomes
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Cites background from "Global epidemiology of nonalcoholic..."
...56), respectively.((16)) The most important histological feature of NAFLD associated with long-term mortality is fibrosis; specifically, zone 3 sinusoidal fibrosis plus periportal fibrosis (stage 2) to advanced (bridging fibrosis [stage 3] or cirrhosis [stage 4])....
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...12).((16)) Given these estimates, one estimates that the prevalence of NASH in the general population ranges between 1....
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...Features of metabolic syndrome (MetS) are not only highly prevalent in patients with NAFLD, but components of MetS also increase the risk of developing NAFLD.((16,18-20)) This bidirectional association between NAFLD and components of MetS has been strongly established....
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...12).((16)) Several studies investigated the natural history of NASH cirrhosis in comparison to patients with hepatitis C cirrhosis....
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...66) per 1,000 person-years.((16)) In another study of patients with HCC, 54....
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Cites background from "Global epidemiology of nonalcoholic..."
...It has been estimated that the world-wide prevalence of NAFLD is around 25% and it is likely to continue to increase.(43) An association between NAFLD and HCC is well established....
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References
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"Global epidemiology of nonalcoholic..." refers background in this paper
...The high prevalence of MetS and hyperlipidemia in NAFLD patients suggests that risk stratification and aggressive treatment is needed to control the risk of CVD in these patients (for reference 129, please see the Supporting information).((1)) Long-term clinical outcomes of NAFLD were also assessed in this study....
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...Guideline for NAFLD (endorsed as the American Association for the Study of Liver Diseases, American College of Gastroenterology, and American Gastroenterological Association NAFLD Guideline) defines significant alcohol use as current or recent alcohol consumption of >21 drinks/week in men and >14 drinks/ week in women.((1)) Although NAFLD is very common, a smaller subgroup of these patients can develop nonalcoholic steatohepatitis (NASH), which is a more progressive type of liver disease....
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...NASH is defined histologically by presence of HS with evidence for hepatocyte damage.((1)) Although some of the pathological features can be associated with hepatic fibrosis (HF), the most important histological feature associated with mortality in NASH is presence of significant fibrosis....
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...In this context, NASH has been recognized as one of the leading causes of cirrhosis in adults in the United States,((1-11)) and NASHrelated cirrhosis is currently the second indication for liver transplants in the United States....
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...Exclusion criteria for the meta-analysis were as follows: (1) The study was a review article or abstract; (2) the study did not identify patients with NAFLD; (3) The study was in a pediatric population (<18 years old); (4) the study did not exclude other causes of liver disease, such as viral hepatitis B and C (HBV/HCV); (5) the study did not report screening for excess alcohol consumption; (6) the study included only groups with a specific metabolic condition, such as morbidly obese and diabetics; (7) the study was conducted in patients with preexisting disease, for example, human immunodeficiency virus (HIV) coinfected; (8) the study diagnosed NAFLD postmortem; and (9) NASH studies were excluded if the diagnosis was not made by histological assessment....
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2,679 citations
"Global epidemiology of nonalcoholic..." refers background in this paper
...Clinically, NAFLD patients tend to be obese, with insulin resistance and/or type 2 diabetes, dyslipidemia, hypertriglyceridemia, and hypertension, which are all risk factors for cardiovascular diseases (CVDs).((10,11)) In fact, prevalence of NAFLD in patients with components of MetS is quite high....
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...The prevalence of NAFLD in the United States is reported to be between 10% and 30%, with similar rates reported from Europe and Asia.((10,19)) The variability of these rates is compounded by the technology used to establish the diagnosis of NAFLD and NASH....
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...In this context, NASH has been recognized as one of the leading causes of cirrhosis in adults in the United States,((1-11)) and NASHrelated cirrhosis is currently the second indication for liver transplants in the United States....
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...The pooled regional NAFLD prevalence estimates among patients diagnosed by blood test were 13.00% (95% CI: 4.44-32.47) for Europe, 12.89% (95% CI: 8.32-19.44) for North America, and 9.26% (95% CI: 7.07-12.05) for Asia....
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...(5-7) In this context, NASH has been recognized as one of the leading causes of cirrhosis in adults in the United States,(1-11) and NASHrelated cirrhosis is currently the second indication for liver transplants in the United States....
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