Journal ArticleDOI
Global incidence of oral and oropharynx cancer in patients younger than 45 years versus older patients: A systematic review.
Aisha A. Hussein,Marco N. Helder,Jan G. de Visscher,C. René Leemans,Boudewijn J.M. Braakhuis,Henrica C.W. de Vet,Tymour Forouzanfar +6 more
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TLDR
It is concluded that a rising trend in oral and oropharynx cancers is observed in young patients worldwide and incidence studies should properly define outcomes in age cohorts and use a consensus cut-off for young patients.About:
This article is published in European Journal of Cancer.The article was published on 2017-09-01. It has received 174 citations till now. The article focuses on the topics: Incidence (epidemiology) & Population.read more
Citations
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Journal ArticleDOI
Management of the Neck in Squamous Cell Carcinoma of the Oral Cavity and Oropharynx: ASCO Clinical Practice Guideline.
Shlomo A. Koyfman,Nofisat Ismaila,Doug Crook,Anil K. D'Cruz,Cristina P. Rodriguez,David J. Sher,Damian Silbermins,Erich M. Sturgis,Terance T. Tsue,Jared Weiss,Sue S. Yom,F. Christopher Holsinger +11 more
TL;DR: This guideline is intended to provide evidence-based recommendations to practicing physicians and others on the management of the neck in patients with squamous cell carcinoma of the oral cavity and oropharynx and to inform the evidence base for this guideline.
Re: Interaction between Tobacco and Alcohol Consumption and the Risk of Cancers of the Upper Aero-Digestive Tract in Brazil. Letter to the editor
W. J. Waddell,Paul Levy +1 more
TL;DR: In this paper, the authors investigated the joint effects of tobacco and alcohol consumption on the risk of squamous cell carcinomas of the upper aero-digestive tract (UADT) using data from a hospital-based case-control study conducted in southern Brazil, 1986-1989.
Journal ArticleDOI
A review of the most promising biomarkers for early diagnosis and prognosis prediction of tongue squamous cell carcinoma.
Aisha A. Hussein,Tymour Forouzanfar,Elisabeth Bloemena,Jgam de Visscher,Ruud H. Brakenhoff,C. René Leemans,Marco N. Helder +6 more
TL;DR: Although more exploratory research is needed with newer methods to identify biomarkers for TSCC, rigorous validation of biomarkers that have already shown unbiased assessment in at least two publications should be considered a high priority.
Journal ArticleDOI
Nimbolide, a neem limonoid inhibits cytoprotective autophagy to activate apoptosis via modulation of the PI3K/Akt/GSK-3β signalling pathway in oral cancer.
Josephraj Sophia,Jaganathan Kowshik,Anju Dwivedi,Sujit K. Bhutia,Bramanandam Manavathi,Rajakishore Mishra,Siddavaram Nagini +6 more
TL;DR: Insight is provided into the molecular mechanisms by which nimbolide augments apoptosis by overcoming the shielding effects of cytoprotective autophagy through modulation of the phosphorylation status of Akt and GSK-3β as well as the ncRNAs miR-126 and HOTAIR.
Journal ArticleDOI
Global Burden of Head and Neck Cancer: Economic Consequences, Health, and the Role of Surgery.
Rolvix H. Patterson,Rolvix H. Patterson,Victoria Fischman,Isaac Wasserman,Isaac Wasserman,Jennifer Siu,Jennifer Siu,Mark G. Shrime,Mark G. Shrime,Johannes J. Fagan,Wayne M. Koch,Blake C. Alkire,Blake C. Alkire +12 more
TL;DR: The mortality burden of head and neck cancer is increasing and disproportionately affects those in low- and middle-income countries and regions with limited surgical workforces, which results in large and growing economic losses in countries that already face significant resource constraints.
References
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Journal ArticleDOI
Cancer statistics, 2016
TL;DR: Overall cancer incidence trends are stable in women, but declining by 3.1% per year in men, much of which is because of recent rapid declines in prostate cancer diagnoses, and brain cancer has surpassed leukemia as the leading cause of cancer death among children and adolescents.
Journal ArticleDOI
Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer
K. Kian Ang,Jonathan Harris,Richard H. Wheeler,Randal S. Weber,David I. Rosenthal,Phuc Felix Nguyen-Tân,William H. Westra,Christine H. Chung,Richard C.K. Jordan,Charles Lu,Harold Kim,Rita Axelrod,C Craig Silverman,Kevin P. Redmond,Maura L. Gillison +14 more
TL;DR: Tumor HPV status is a strong and independent prognostic factor for survival among patients with oropharyngeal cancer and the risk of death significantly increased with each additional pack-year of tobacco smoking.
Journal ArticleDOI
Global epidemiology of oral and oropharyngeal cancer
TL;DR: This review presents data on incidence, mortality, survival and trends in cancers of the lip, oral cavity and oropharynx using available recent data sources around the world to gain insight into the geographic variations in the incidence of this cancer in the globe.
Journal ArticleDOI
Case-control study of human papillomavirus and oropharyngeal cancer.
Aimée R. Kreimer,Raphael P. Viscidi,Michael Pawlita,Carole Fakhry,Wayne M. Koch,William H. Westra,Maura L. Gillison +6 more
TL;DR: Oropharyngeal cancer was significantly associated with oral HPV type 16 (HPV-16) infection, and the degree of association increased with the number of vaginal-sex and oral-sex partners, among subjects with or without the established risk factors of tobacco and alcohol use.
Journal ArticleDOI
Improved Survival of Patients With Human Papillomavirus–Positive Head and Neck Squamous Cell Carcinoma in a Prospective Clinical Trial
Carole Fakhry,William H. Westra,S. Li,Anthony J. Cmelak,John A. Ridge,Harlan A. Pinto,Arlene A. Forastiere,Maura L. Gillison +7 more
TL;DR: For patients with HNSCC of the oropharynx, tumor HPV status is strongly associated with therapeutic response and survival and, after adjustment for age, tumor stage, and ECOG performance status, lower risks of progression and death are found.
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Anil K. Chaturvedi,Eric A. Engels,Ruth M. Pfeiffer,Brenda Y. Hernandez,Weihong Xiao,Esther Kim,Bo Jiang,Marc T. Goodman,Maria Sibug-Saber,Wendy Cozen,Lihua Liu,Charles F. Lynch,Nicolas Wentzensen,Richard C.K. Jordan,Sean F. Altekruse,William F. Anderson,Philip S. Rosenberg,Maura L. Gillison +17 more