Global research priorities in rheumatic fever and rheumatic heart disease
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TLDR
There are good prospects for controlling these RF and RHD over the next decade, with concerted efforts, strong links to clinical and public health infrastructure, and advocacy and funding support from the international community.Abstract:
We now stand at a critical juncture for rheumatic fever (RF) and rheumatic heart disease (RHD) control. In recent years, we have seen a surge of interest in these diseases in regions of the world where RF/RHD mostly occur. This brings real opportunities to make dramatic progress in the next few years, but also real risks if we miss these opportunities. Most public health and clinical approaches in RF/RHD arose directly from programmes of research. Many unanswered questions remain, including those around how to implement what we know will work, so research will continue to be essential in our efforts to bring a global solution to this disease. Here we outline our proposed research priorities in RF/RHD for the coming decade, grouped under the following four challenges: Translating what we know already into practical RHD control; How to identify people with RHD earlier, so that preventive measures have a higher chance of success; Better understanding of disease pathogenesis, with a view to improved diagnosis and treatment of ARF and RHD; and Finding an effective approach to primary prevention. We propose a mixture of basic, applied, and implementation science. With concerted efforts, strong links to clinical and public health infrastructure, and advocacy and funding support from the international community, there are good prospects for controlling these RF and RHD over the next decade.read more
Citations
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Journal ArticleDOI
Variations in Cause and Management of Atrial Fibrillation in a Prospective Registry of 15 400 Emergency Department Patients in 46 Countries The RE-LY Atrial Fibrillation Registry
Jonas Oldgren,Jeff S. Healey,Michael D. Ezekowitz,Patrick J. Commerford,Alvaro Avezum,Prem Pais,Jun Zhu,Petr Jansky,Alben Sigamani,Carlos A. Morillo,Lisheng Liu,Albertino Damasceno,Alex Grinvalds,Juliet Nakamya,Paul A. Reilly,Katalin Keltai,Isabelle C. Van Gelder,Afzalhussein Yusufali,Eiichi Watanabe,Lars Wallentin,Stuart J. Connolly,Salim Yusuf +21 more
TL;DR: In this article, the most common sustained arrhythmia is atrial fibrillation (AF) and little is known about patients in a primary care setting from high-, middle-, and low-income countries.
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Position statement of the World Heart Federation on the prevention and control of rheumatic heart disease
TL;DR: Existing barriers to RF and RHD control are reviewed and existing actions required to change the trajectory of control for these diseases are identified.
Journal ArticleDOI
Acute Rheumatic Fever and Rheumatic Heart Disease Incidence and Progression in the Northern Territory of Australia, 1997 to 2010
TL;DR: In this article, a control program, including a disease register, in the Northern Territory of Australia where the Indigenous population has high rates of acute rheumatic fever (ARF) and its sequel, Rheumatic heart disease (RHD), allowed the authors to examine current disease incidence and progression.
Journal ArticleDOI
Congenital heart disease and rheumatic heart disease in Africa: recent advances and current priorities
TL;DR: There is an urgent need for comprehensive service frameworks to improve access and level of care and services for patients, educational programmes to reinforce the importance of prevention and early diagnosis and a relevant research agenda focusing on the African context.
Journal ArticleDOI
Screening for rheumatic heart disease: current approaches and controversies
TL;DR: The natural history of RHD in children with subclinical abnormalities detected by echocardiographic screening remains unknown, and long-term follow-up studies are needed to evaluate the significance of detecting these changes at an early stage.
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