Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary
Citations
1,122 citations
Cites background or methods from "Global Strategy for the Diagnosis, ..."
...categorization of patients at diagnosis(14)....
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...recommendations for initial treatment and subsequent follow up for each group (14)....
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...The Global initiative for the management of chronic Obstructive Lung Disease (GOLD) 2017 strategy document recommended that an assessment (ABCD grouping) based on symptoms and exacerbation risk should be performed after the initial diagnosis of COPD (14)....
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295 citations
Cites methods from "Global Strategy for the Diagnosis, ..."
...The current treatment strategy for COPD includes inhaled corticosteroids, anticholinergics, and β2-agonists, which have been primarily effective in controlling the symptoms but do not cure the underlying disease.(184) The major challenges in the nanotherapeutics of COPD are airway defense, mucus hypersecretion and severe inflammation....
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292 citations
Cites background or methods from "Global Strategy for the Diagnosis, ..."
...”(5,6) In the 2017 revision, GOLD had revised the definition of COPD to include “persistent respiratory symptoms” as an essential feature; however, the reasoning behind this has not been provided and the definition is carried through into the current version.(5,6) Chapter 1 addresses the global burden of COPD and cautions the reader about the expected increase in the prevalence and burden of COPD due to continued exposure to risk factors and aging of the world’s population....
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...As with previous editions, the 2018 update(5) seeks to provide comprehensive evidence-based guidance for the diagnosis, management, and prevention of COPD.(5,6)...
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...70, which “confirms the presence of persistent airflow limitation,” (2) “appropriate symptoms” including dyspnea, chronic cough, sputum production, or wheezing, and (3) “significant exposures to noxious stimuli” such as a history of smoking cigarettes, or other environmental exposures.(5,6) Most research studies of patients with COPD define a “significant exposure” to cigarettes as 10 pack-years; however, GOLD does not address quantification of smoking history....
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...The bulk of COPD exacerbationsd80%dcan and should be successfully managed in the outpatient setting.(6) On-hand dual prescriptions for oral corticosteroids and antibiotics are a staple of successful COPD action plans....
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...1490 historical use as an inclusion criterion for entry into clinical trials.(5,6) Screening spirometry is, appropriately, not recommended for asymptomatic patients, even those with risk factors....
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248 citations
References
7,710 citations
"Global Strategy for the Diagnosis, ..." refers background in this paper
...Two studies of low-dose chest computed tomography (LDCT) screening report improved survival in subjects aged 55-74 years, current smokers or those who quit within the previous 15 years, with a smoking history of at least 30 packyears.(337,338) LDCT is now recommended in the U....
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4,312 citations
"Global Strategy for the Diagnosis, ..." refers background in this paper
...Short-acting inhaled beta2-agonists, with or without short-acting anticholinergics, are the initial bronchodilators recommended for acute treatment of exacerbations.(258,259) There are no significant differences in FEV1 when using metered dose inhalers (MDI) (with or without a spacer device) or nebulizers to deliver the agent,(260) although the latter may be an easier delivery method for sicker patients....
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3,688 citations
"Global Strategy for the Diagnosis, ..." refers methods in this paper
...The BODE (Body mass index, Obstruction, Dyspnea, and Exercise) method gives a composite score that is a better predictor of subsequent survival than any single component.(71) Simpler alternatives that do not include exercise testing need validation to confirm suitability for routine clinical use....
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3,037 citations
2,835 citations