Globular Adiponectin as a Complete Mesoangioblast Regulator: Role in Proliferation, Survival, Motility, and Skeletal Muscle Differentiation
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...In particular, gAd promotes myogenesis inmyoblasts [10], satellite cells [11], and induces migration and muscle differentiation in the non-resident muscle precursors, mesoangioblasts [13]....
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...In accordance with our previous findings showing that gAd elicits a motile program in satellite cells [11] and in mesoangioblasts [13], we report that gAd elicits a motile program in myoblasts through a mechanism dependent on autophagy activation....
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...The involvement of adiponectin inmuscle health is supported by our previous results showing that the ex vivo treatment with gAd protects mesoangioblasts from in vivo apoptosis, leading to increased engraftment of the cells in the muscles of dystrophic mice [13]....
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...In muscle precursor cells, gAd induces different effects ranging from metalloproteinase production, migration, apoptosis inhibition, and myogenesis [11,13]....
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...Since gAd promotes myogenesis in muscle precursor cells [10,11,13], we then investigated the involvement of gAd-activated autophagy in the pro-differentiating function of the hormone....
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"Globular Adiponectin as a Complete ..." refers background in this paper
...The peculiarity of adiponectin compared with sphingosine 1-phosphate is that the adipokine is produced by adipose tissue in an inverse relationship with fat mass, and its level is strongly decreased in diabetic patients (Weyer et al., 2001; Rasouli and Kern, 2008)....
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