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Glossary of Indian Medicinal Plants
01 Jan 1956-
About: The article was published on 1956-01-01 and is currently open access. It has received 5524 citations till now. The article focuses on the topics: Glossary.
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TL;DR: The different fractions of B. serrata showed prompt anti-inflammatory and analgesic activity due to the inhibition of 5-lipoxygenase enzyme, as determined by acetic acid induced writhing response, formalin induced pain, hot plate and tail flick method.
Abstract: The study was designed to investigate the anti-inflammatory and analgesic effect of different fractions of Boswellia serrata The effect of different fractions of Boswellia serrata were studied using carrageenan induced paw edema, acetic acid induced writhing response, formalin induced pain, hot plate and tail flick method for studying anti-inflammatory and analgesic activity, respectively The different fractions of B serrata, essential oil (10 ml/kg), gum (100 mg/kg, resin (100 mg/kg) oleo-resin (100 mg/kg) and oleo-gum-resin (100 mg/kg) significantly reduces carrageenan induced inflammation in rats and shows analgesic activity, as determined by acetic acid induced writhing response, formalin induced pain, hot plate and tail flick method The different fractions of B serrata showed prompt anti-inflammatory and analgesic activity due to the inhibition of 5-lipoxygenase enzyme Keywords: Analgesic; Boswellia serrata; Inflammation; 5- lipoxygenase; Burseraceae
48 citations
01 Jan 2010
TL;DR: The crude extract showed a broad spectrum of antimicrobial activity by inhibiting both the groups of bacteria and fungus, and the Minimum Inhibitory Concentration (MIC) of various spice-extracts on some bacterial and-fungal strains.
Abstract: The aim of the study is to assess the antimicrobial activity and to determine the Minimum Inhibitory Concentration (MIC) of various spice extract on some bacterial and fungal strains. The antimicrobial activity of alcoholic and aqueous extracts of asafoetida, ginger, cinnamon and cardamom extract was tested against B. subtilis, S. aureus, E. coli, P. aeruginosa, C. albicians & P. chrysogenum by agar well diffusion method. The crude extract showed a broad spectrum of antimicrobial activity by inhibiting both the groups of bacteria and fungus. Agar well diffusion assay for antimicrobial activity yielded the inhibitory zone of 16 to 34 mm diameter for asafoetida, 12 to 18mm diameter for cinnamon, 15 to 35mm diameter for ginger and 13 to 21 mm for cardamom extracts. The MIC value ranged between 12.5 mg/ml to 3.125 mg/ml with an exception of cinnamon alcohol extract against E. coli for which the calculated MIC was 25mg/ml.
48 citations
TL;DR: Data indicate that the antidiarrhoeal and spasmolytic effects of the crude extract of Mentha longifolia are mediated through the presence of CCB‐like constituent(s), concentrated in the petroleum spirit fraction, and this study provides indirect evidence for its medicinal use in diarrhoea andSpasm.
Abstract: Mentha longifolia has a reputation in traditional medicine in the indications of diarrhoea and gut spasm. This study was carried out to provide a possible pharmacological basis for its medicinal use in hyperactive gut disorders. In a castor oil induced diarrhoeal model, the crude extract of Mentha longifolia (Ml.Cr), at doses of 100-1000 mg/kg, provided 31-80% protection, similar to loperamide. In isolated rabbit jejunum preparations, Ml.Cr caused inhibition of spontaneous and high K(+)-induced contractions, with respective EC50 values of 1.80 (1.34-2.24; n = 6-8) and 0.60 mg/mL (0.37-0.85; n = 6-8), which suggests spasmolytic activity, mediated possibly through calcium channel blockade (CCB). The CCB activity was further confirmed when pretreatment of the tissue with Ml.Cr (0.3-1 mg/mL) caused a rightward shift in the Ca(++) concentration-response curves (CRCs), similar to verapamil. Loperamide also inhibited spontaneous and high K(+)-induced contractions and shifted the Ca(++) CRCs to the right. Activity-directed fractionation revealed that the petroleum spirit fraction was more potent than the parent crude extract and aqueous fraction. These data indicate that the antidiarrhoeal and spasmolytic effects of the crude extract of Mentha longifolia are mediated through the presence of CCB-like constituent(s), concentrated in the petroleum spirit fraction and this study provides indirect evidence for its medicinal use in diarrhoea and spasm.
48 citations
48 citations