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Glossary of Indian Medicinal Plants
01 Jan 1956-
About: The article was published on 1956-01-01 and is currently open access. It has received 5524 citations till now. The article focuses on the topics: Glossary.
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TL;DR: Treated oral cancer patients were neutropenic and prone to secondary infection of microbes and the medicinal plant can prove as effective antimicrobial agent to check the secondary infections in treated cancer patients.
Abstract: Background: Suppression of immune system in treated cancer patients may lead to secondary infections that obviate the need of antibiotics. In the present study, an attempt was made to understand the occurrence of secondary infections in immuno-suppressed patients along with herbal control of these infections with the following objectives to: (a) isolate the microbial species from the treated oral cancer patients along with the estimation of absolute neutrophile counts of patients (b) assess the in vitro antimicrobial activity medicinal plants against the above clinical isolates. Methods: Blood and oral swab cultures were taken from 40 oral cancer patients undergoing treatment in the radiotherapy unit of Regional Cancer Institute, Pt. B.D.S. Health University, Rohtak, Haryana. Clinical isolates were identified by following general microbiological, staining and biochemical methods. The absolute neutrophile counts were done by following the standard methods. The medicinal plants selected for antimicrobial activity analysis were Asphodelus tenuifolius Cav., Asparagus racemosus Willd., Balanites aegyptiaca L., Cestrum diurnum L., Cordia dichotoma G. Forst, Eclipta alba L., Murraya koenigii (L.) Spreng. , Pedalium murex L., Ricinus communis L. and Trigonella foenum graecum L. The antimicrobial efficacy of medicinal plants was evaluated by modified Kirby-Bauer disc diffusion method. MIC and MFC were investigated by serial two fold microbroth dilution method. Results: Prevalent bacterial pathogens isolated were Staphylococcus aureus (23.2%), Escherichia coli (15.62%), Staphylococcus epidermidis (12.5%), Pseudomonas aeruginosa (9.37%), Klebsiella pneumonia (7.81%), Proteus mirabilis (3.6%), Proteus vulgaris (4.2%) and the fungal pathogens were Candida albicans (14.6%), Aspergillus fumigatus (9.37%). Out of 40 cases, 35 (87.5%) were observed as neutropenic. Eight medicinal plants (A. tenuifolius, A. racemosus, B. aegyptiaca, E. alba, M. koenigii, P. murex R. communis and T. foenum graecum) showed significant antimicrobial activity (P < .05) against most of the isolates. The MIC and MFC values were ranged from 31 to 500 μg/ml. P. aeruginosa was observed highest susceptible bacteria (46.6%) on the basis of susceptible index. Conclusion: It can be concluded that treated oral cancer patients were neutropenic and prone to secondary infection of microbes. The medicinal plant can prove as effective antimicrobial agent to check the secondary infections in treated cancer patients.
118 citations
TL;DR: The results confirm the use of this plant in folk medicine as an anti-inflammatory and antimicrobial herbal drug and show the antimicrobial effect observed was lower at the two doses employed.
118 citations
01 Jan 2010
TL;DR: Berberine has been tested clinically in the treatment of oriental sore, diarrhea, trachoma diabetes mellitus type-2, hypercholesterolemia, and congestive cardiac failure, with potential for drug-development.
Abstract: Berberine is an isoquinoline alkaloid, present in roots and stem-bark of Berberis species. Berberine based formulations, are widely used in traditional systems of medicine including, Ayurveda and Traditional Chinese Medicine. Berberine has demonstrated wide range of pharmacological activities including; antihypertensive, anti-inflammatory, antioxidant, antidepressant, anticancer, anti-diarrhoeal, cholagouge, hepatoprotective and above all, antimicrobial. Recent studies, have thrown light on antidiabetic and hypolipidemic activities of the alkaloid. Berberine has been tested clinically in the treatment of oriental sore, diarrhea, trachoma diabetes mellitus type-2, hypercholesterolemia, and congestive cardiac failure. The present review, discusses preclinical and clinical investigations on berberine, with potential for drug-development.
117 citations
TL;DR: The isolation and purification of lupeol acetate from the methanolic root extract of Indian medicinal plant Hemidesmus indicus (L.) R.Br.
117 citations
Journal Article•
TL;DR: Kalmegh extract protects lipids, haemoglobin and red blood cells from lipid peroxidation, prevents oxidative damage and inhibits binding to toxic metabolites to DNA.
Abstract: Kalmegh ( Andrographis paniculata Nees) has wide range of medicinal and pharmacological applications. It is used in different traditional systems of medicine and exhibits anti-inflammatory, anti-HIV, antibacterial, antioxidant, antiparasitic, antispasmodic, antidiabetic, anticarcinogenic, antipyretic, hepatoprotective, nematocidal and various other activities. It is a potent scavenger of a variety of reactive oxygen species (ROS) including superoxide anion, hydroxyl radical, singlet oxygen, peroxynitrite and nitric oxide. Among several active chemical constituents, andrographolide, neoandrographolide and dehydroandrographolide are most important bioprotectants with wide range of therapeutic applications. Andrographolides significantly inhibit the expression of iNOS, COX-2, mRNA, protein, enzyme activity in RAW 264.7 macrophages that involves in anti-inflammatory activity. Kalmegh extract protects lipids, haemoglobin and red blood cells from lipid peroxidation. It prevents oxidative damage and inhibits binding to toxic metabolites to DNA. Safety evaluation studies indicate that kalmegh is well tolerated at very high dose without any toxic effects.
117 citations