GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure
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Cites background from "GLP-1 receptor activation and Epac2..."
...GLP-1 also has been shown to reduce blood pressure via an atrial natriuretic pathway.(479) Previous data have suggested that GLP-1 is involved in maintaining normal cardiac structure and function, as evidenced by the increased thickness, impaired contractility, and elevated end diastolic pressure of the left ventricle, as well as diastolic dysfunction and reduced cardiac reserve observed in knockout mice deficient in the GLP-1 receptor....
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Cites background from "GLP-1 receptor activation and Epac2..."
...In mice, liraglutide reduces angiotensin II (Ang-II) stimulation of systolic and diastolic BP, an effect that is absent GLP-1R KO mice or by pretreatment with exendin (9e39) or the natriuretic peptide receptor antagonist anantin [640]....
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...In wildtype but not GLP-1R KO mice, liraglutide stimulates the secretion of natriuretic peptide (ANP) from the atrial cardiomyocytes and liraglutide fails to affect natriuresis and vasorelaxation in mice deficient for ANP [640]....
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...Liraglutide stimulation of cardiac ANP secretion is PKA independent but mediated by Epac2 in a cAMP and PLCdependent manner [640]....
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...In mice, liraglutide blunts hypertension induced by angiotensin II (Ang-II), an effect that is absent in GLP-1R KO mice, and is also attenuated upon pretreatment of WT mice with exendin (9e39) [640]....
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...Indeed, liraglutide stimulates relaxation of the aorta [640] but GLP-1 might also indirectly lower BP via its ability to reduce body weight....
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