GluA1 Phosphorylation Contributes to Postsynaptic Amplification of Neuropathic Pain in the Insular Cortex
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Cites background from "GluA1 Phosphorylation Contributes t..."
...Subsequent mouse knock-in experiments also revealed that increased expression of the AMPA receptor in the insular cortex was responsible for long-term potentiation of glutamate transmission during neuropathic pain (Qui et al., 2014)....
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...Subsequent mouse knock-in experiments also revealed that increased expression of the AMPA receptor in the insular cortex was responsible for long term potentiation of glutamate transmission during neuropathic pain (Qui et al., 2014)....
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...Neuropathic pain in a mouse model has been shown to be associated with synaptic plasticity in the insular cortex (Qui et al., 2014)....
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155 citations
Cites background from "GluA1 Phosphorylation Contributes t..."
...Our previous study showed that persistent pain can bring about a series of neural plastic changes mediated by the synaptic GluA1 subunit of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) [9]....
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...And this enhancement relies on an increased amount and sensitivity of the synaptic GluA1 subunit of AMPARs, but not the GluA2/3 subunit [9]....
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109 citations
References
15,681 citations
"GluA1 Phosphorylation Contributes t..." refers methods in this paper
...The anatomical terminology is based on the atlas of Franklin and Paxinos (1997)....
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519 citations
"GluA1 Phosphorylation Contributes t..." refers background in this paper
...Insular cortex and neuropathic pain The insular cortex is critical in pain and sensory perception (Ostrowsky et al., 2002; Mazzola et al., 2009, 2012)....
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..., 2008), and direct electrical stimulation of the insular cortex could elicit painful and somatic sensations, supporting the critical roles of the insular cortex in acute pain and sensory perception (Ostrowsky et al., 2002; Mazzola et al., 2009; Mazzola et al., 2012)....
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...…stimuli (Henderson et al., 2008), and direct electrical stimulation of the insular cortex could elicit painful and somatic sensations, supporting the critical roles of the insular cortex in acute pain and sensory perception (Ostrowsky et al., 2002; Mazzola et al., 2009; Mazzola et al., 2012)....
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477 citations
"GluA1 Phosphorylation Contributes t..." refers methods in this paper
...Subcellular fractionation was conducted on tissue from C57BL/6 mice or transgenic mice using an adapted protocol (Pacchioni et al., 2009; Milnerwood et al., 2010)....
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...The synaptosome was digested to yield an insoluble PSD-enriched (synaptic) membrane fraction and a soluble non-PSD enriched (peri/extrasynaptic and presynaptic) membrane fraction (Pacchioni et al., 2009; Milnerwood et al., 2010)....
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477 citations
451 citations
"GluA1 Phosphorylation Contributes t..." refers methods in this paper
...…the role of phosphorylation in the upregulation of insular GluA1 during neuropathic pain, we used two lines of mutant mice specifically lacking phosphorylation of the Ser845 site (GluA1–S845A mutants) or lacking phosphorylation of the Ser831 site (GluA1–S831A mutants; Clem and Huganir, 2010)....
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