Glucagon as a Therapeutic Approach to Severe Hypoglycemia: After 100 Years, Is It Still the Antidote of Insulin?
Francesca Porcellati,Stefania Di Mauro,Alessio Mazzieri,Alessandra Scamporrino,Agnese Filippello,Michelantonio De Fano,Carmine G. Fanelli,Francesco Purrello,Roberta Malaguarnera,Salvatore Piro +9 more
- Vol. 11, Iss: 9, pp 1281
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TLDR
In this article, a review of the important aspects of this field is presented, and the possibility to have novel strategies and scientific knowledge concerning hypoglycemia could represent an enormous benefit.Abstract:
Hypoglycemia represents a dark and tormented side of diabetes mellitus therapy. Patients treated with insulin or drug inducing hypoglycemia, consider hypoglycemia as a harmful element, which leads to their resistance and lack of acceptance of the pathology and relative therapies. Severe hypoglycemia, in itself, is a risk for patients and relatives. The possibility to have novel strategies and scientific knowledge concerning hypoglycemia could represent an enormous benefit. Novel available glucagon formulations, even now, allow clinicians to deal with hypoglycemia differently with respect to past years. Novel scientific evidence leads to advances concerning physiopathological mechanisms that regulated glycemic homeostasis. In this review, we will try to show some of the important aspects of this field.read more
Citations
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Safety, tolerability, pharmacokinetics and pharmacodynamics of multiple ascending doses of the novel long-acting glucagon analogue HM15136 in overweight and obese patients with co-morbidities.
TL;DR: In this article , the authors evaluated the safety, tolerability, pharmacokinetics and pharmacodynamics of multiple ascending doses of the novel long-acting glucagon analogue HM15136 in overweight/obese patients with co-morbidities, with and without type 2 diabetes (T2D).
Journal ArticleDOI
Integrated safety and efficacy analysis of dasiglucagon for the treatment of severe hypoglycaemia in individuals with type 1 diabetes
Simon Heller,Tadej Battelino,Timothy L. Bailey,Thomas R. Pieber,Ulrike Hövelmann,L. Plum-Mörschel,Anita Melgaard,Ronnie Aronson,Linda A. DiMeglio,Thue Johansen,Thomas Danne +10 more
TL;DR: In this article , the safety and efficacy of dasiglucagon, a glucagon analogue available in a ready-to-use aqueous formulation, to treat severe hypoglycaemia (SH) in type 1 diabetes (T1D) was evaluated.
References
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Effects of intensive glucose lowering in type 2 diabetes
Hertzel C. Gerstein,Michael Miller,Robert P. Byington,David C. Goff,J. Thomas Bigger,John B. Buse,William C. Cushman,Saul Genuth,Faramarz Ismail-Beigi,Faramarz Ismail-Beigi,Richard H. Grimm,Jeffrey L. Probstfield,Denise G. Simons-Morton,William T. Friedewald +13 more
TL;DR: In this paper, the authors investigated whether intensive therapy to target normal glycated hemoglobin levels would reduce cardiovascular events in patients with type 2 diabetes who had either established cardiovascular disease or additional cardiovascular risk factors.
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Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes.
Anushka Patel,Stephen MacMahon,John Chalmers,Bruce Neal,Laurent Billot,Mark Woodward,Mark Woodward,Michel Marre,Mark E. Cooper,Paul Glasziou,Paul Glasziou,Diederick E. Grobbee,Pavel Hamet,Stephen B. Harrap,Simon Heller,Lisheng Liu,Giuseppe Mancia,Carl Erik Mogensen,C. Y. Pan,Neil R Poulter,Anthony Rodgers,Bryan Williams,Severine Bompoint,Bastiaan E. de Galan,Bastiaan E. de Galan,Rohina Joshi,F. Travert +26 more
TL;DR: A strategy of intensive glucose control, involving gliclazide (modified release) and other drugs as required, that lowered the glycated hemoglobin value to 6.5% yielded a 10% relative reduction in the combined outcome of major macrovascular and microvascular events, primarily as a consequence of a 21%relative reduction in nephropathy.
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Glucose Control and Vascular Complications in Veterans with Type 2 Diabetes
William C. Duckworth,Carlos Abraira,Thomas E. Moritz,Domenic J. Reda,Nicholas V. Emanuele,Peter D. Reaven,Franklin J. Zieve,Jennifer B. Marks,Stephen N. Davis,Rodney A. Hayward,Stuart R. Warren,Steven Goldman,Madeline McCarren,Mary Ellen Vitek,William G. Henderson,Grant D. Huang +15 more
TL;DR: Intensive glucose control in patients with poorly controlled type 2 diabetes had no significant effect on the rates of major cardiovascular events, death, or microvascular complications with the exception of progression of albuminuria.
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Severe Hypoglycemia and Risks of Vascular Events and Death
Sophia Zoungas,Sophia Zoungas,Anushka Patel,John Chalmers,Bastiaan E. de Galan,Bastiaan E. de Galan,Qiang Li,Laurent Billot,Mark Woodward,Mark Woodward,Toshiharu Ninomiya,Bruce Neal,Stephen MacMahon,Diederick E. Grobbee,Andre Pascal Kengne,Michel Marre,Simon Heller +16 more
TL;DR: Severe hypoglycemia was strongly associated with increased risks of a range of adverse clinical outcomes, including respiratory, digestive, and skin conditions, and no relationship was found between repeated episodes of severe hypglycemia and vascular outcomes or death.
Journal ArticleDOI
Hypoglycemia and Diabetes: A Report of a Workgroup of the American Diabetes Association and The Endocrine Society
Elizabeth R. Seaquist,John E. Anderson,Belinda P. Childs,Philip E. Cryer,Samuel Dagogo-Jack,Lisa Fish,Simon Heller,Henry Rodriguez,James L. Rosenzweig,Robert A. Vigersky +9 more
TL;DR: The evidence about the impact of hypoglycemia on patients with diabetes that has become available since the past reviews by the American Diabetes Association and The Endocrine Society is reviewed to provide guidance about how this new information should be incorporated into clinical practice.
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