Journal ArticleDOI
Glucagon-like peptide-1 7-36: a physiological incretin in man.
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TLDR
The observation of greatly increased postprandial plasma GLP-1 7-36 levels in patients with postgastrectomy dumping syndrome suggests that it may mediate the hyperinsulinaemia and reactive hypoglycaemia of this disorder.About:
This article is published in The Lancet.The article was published on 1987-12-05. It has received 1897 citations till now. The article focuses on the topics: Incretin & Postprandial.read more
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Journal ArticleDOI
Biology of Incretins: GLP-1 and GIP
TL;DR: This review focuses on the mechanisms regulating the synthesis, secretion, biological actions, and therapeutic relevance of the incretin peptides glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1).
Journal ArticleDOI
The Physiology of Glucagon-like Peptide 1
TL;DR: The main actions of GLP-1 are to stimulate insulin secretion and to inhibit glucagon secretion, thereby contributing to limit postprandial glucose excursions and acts as an enterogastrone and part of the "ileal brake" mechanism.
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The biology of incretin hormones.
TL;DR: Current concepts of incretin action are summarized and the potential therapeutic utility of GLP-1 receptor agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors for the treatment of type 2 diabetes is highlighted.
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Inhibition of food intake in obese subjects by peptide YY3-36.
Rachel L. Batterham,Mark Cohen,Sandra M. Ellis,Carel W. le Roux,Dominic J. Withers,Gary Frost,Mohammad A. Ghatei,Stephen R. Bloom +7 more
TL;DR: It is found that obese subjects were not resistant to the anorectic effects of PYY, and endogenous PYY levels were low in obese subjects, suggesting that PYY deficiency may contribute to the pathogenesis of obesity.
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Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus.
TL;DR: In mild type-2 diabetes, GLP-1 [7-36 amide], in contrast to GIP, retains much of its insulinotropic activity and lowers glucagon concentrations.
References
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Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity
W M Hunter,F. C. Greenwood +1 more
TL;DR: Current procedures for the immunological assay of protein hormones in human plasma require the routine preparation of hormones labelled with iodine-131 of high specific activity, and this work demonstrates the importance of knowing the carrier and removal status of iodine.
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Stimulation of insulin secretion by gastric inhibitory polypeptide in man.
TL;DR: It is concluded that GIP is a potent insulinotropic hormone and probably takes part in physiological potentiation of insulin secretion in response to hyperglycemia during absorption of nutrients from the intestine.
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Antibodies to bradykinin and angiotensin: a use of carbodiimides in immunology.
TL;DR: Antibodies to bradykinin and angiotensin have been produced in rabbits by the use of conjugates containing albumin and the hapten, covalently bound using water-soluble carbodiimide reagents.
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Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas.
TL;DR: It is reported that a novel glucagon-like peptide, co-encoded with glucagon in the glucagon gene is a potent insulinotropic factor, and suggests that GLP-I(7-37) participates in the physiological regulation of insulin secretion.
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Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing.
Svetlana Mojsov,Gerhard Heinrich,Ira B. Wilson,Mariella Ravazzola,Lelio Orci,Joel F. Habener +5 more
TL;DR: It is concluded that diversification of preproglucagon gene expression occurs at the level of cell-specific post-translational processing.