Journal ArticleDOI
Glutamic acid decarboxylase inhibition and ultrastructural changes by the convulsant drug allylglycine.
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TLDR
In the convulsant rat, ultra-structural alterations of some nerve endings of the cerebral cortex were observed and altered nerve endings were preferentially found in the GAD-rich (nonaminergic) fraction of isolated nerve endings.About:
This article is published in Biochemical Pharmacology.The article was published on 1969-01-01. It has received 86 citations till now. The article focuses on the topics: Allylglycine & Glutamate decarboxylase.read more
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Animal models of the epilepsies
TL;DR: A review of animal models of the epilepsies can be found in this paper, where the authors present a review of 50 models for simple partial seizures, including topical convulsants, acute electrical stimulation, cortically implanted metals, cryogenic injury, and complex partial seizures.
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Glycine uptake in rat central nervous system slices and homogenates: evidence for different uptake systems in spinal cord and cerebral cortex
TL;DR: Evidence is presented that glycine is taken up by two different transport systems in rat CNS tissue slices; one system has relatively low affinity for glycine and predominates in cerebral cortex, cerebellum and mid‐brain, while the other has a higher affinity for glucose and is detectable only in spinal cord, medulla and pons.
Journal ArticleDOI
Excitation of mammalian central neurones by acidic amino acids.
TL;DR: The depolarization of motoneurones by dl -homocysteate was not altered by changes in intracellular chloride concentration, or extracellular concentrations of tetrodotoxin sufficient to suppress spike generation, and the action of the amino acid thus probably resembles that of synaptically released excitatory transmitters.
Journal ArticleDOI
High affinity l-[3h]glutamate binding to postsynaptic receptor sites on rat cerebellar membranes.
A. C. Foster,Peter J. Roberts +1 more
TL;DR: Comparison of the potencies of a wide range of compounds with known pharmacological activities, demonstrated that their ability to displace specific glutamate binding was consistent with specific interactions with glutamate receptors.
References
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Journal ArticleDOI
The excitation and depression of spinal neurones by structurally related amino acids.
David R. Curtis,J. C. Watkins +1 more
TL;DR: A survey of the activity of compounds structurally related to both series of amino acids finds that one of them or a related substance may have excitatory transmitter function within the nervous system.
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Cholinergic and non-cholinergic nerve endings in rat brain. I. Isolation and subcellular distribution of acetylcholine and acetylcholinesterase.
Journal ArticleDOI
Subcellular distribution of the enzymes of the glutamic acid, glutamine and gamma-aminobutyric acid cycles in rat brain.
L. Salganicoff,E. M. De Robertis +1 more
TL;DR: The function of this group of amino acids seems to be related to the complex structure of the CNS and the existence of numerous compartments and metabolic pools.
Journal ArticleDOI
THE FLUORIMETRIC MEASUREMENT OF GLUTAMIC DECARBOXYLASE and ITS DISTRIBUTION IN BRAIN
TL;DR: It has been found that certain amino acids and indole derivatives, when allowed to react with ninhydrin at an alkaline pHS, form highly fluorescent products that can be measured in as little as 3 ,ug dry weight of brain tissue.
Journal Article
Convulsant hydrazides. I. In vitro and in vivo inhibition of vitamin B6 enzymes by convulsant hydrazides.
K. F. Killam,J. A. Bain +1 more
TL;DR: A comparison of free amino acids in brain extracts indicated that semicarbazide-induced seizures are associated with a decreased level of gamma-aminobutyric acid; pentylenetetrazol seizures were not accompanied by changes in amino acid levels.
Related Papers (5)
Seizures induced by allylglycine, 3-mercaptopropionic acid and 4-deoxypyridoxine in mice and photosensitive baboons, and different modes of inhibition of cerebral glutamic acid decarboxylase.
R. W. Horton,B. S. Meldrum +1 more