Glutamine addiction: a new therapeutic target in cancer.
David R. Wise,Craig B. Thompson +1 more
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TLDR
In many cancer cells, glutamine is the primary mitochondrial substrate and is required for maintenance of mitochondrial membrane potential and integrity and for support of the NADPH production needed for redox control and macromolecular synthesis.About:
This article is published in Trends in Biochemical Sciences.The article was published on 2010-08-01 and is currently open access. It has received 1433 citations till now. The article focuses on the topics: Glutamine & Amino acid synthesis.read more
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Mitochondria and cancer
TL;DR: Cancer cells then reprogramme adjacent stromal cells to optimize the cancer cell environment and activate out-of-context programmes that are important in development, stress response, wound healing and nutritional status.
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Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway
Jaekyoung Son,Costas A. Lyssiotis,Costas A. Lyssiotis,Haoqiang Ying,Xiaoxu Wang,Sujun Hua,Matteo Ligorio,Rushika M. Perera,Cristina R. Ferrone,Edouard Mullarky,Edouard Mullarky,Ng Shyh-Chang,Ya'an Kang,Jason B. Fleming,Nabeel Bardeesy,John M. Asara,Marcia C. Haigis,Ronald A. DePinho,Lewis C. Cantley,Lewis C. Cantley,Alec C. Kimmelman +20 more
TL;DR: The identification of a non-canonical pathway of glutamine use in human pancreatic ductal adenocarcinoma (PDAC) cells is reported and it is established that the reprogramming of glutamines metabolism is mediated by oncogenic KRAS, the signature genetic alteration in PDAC, through the transcriptional upregulation and repression of key metabolic enzymes in this pathway.
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From Krebs to clinic: glutamine metabolism to cancer therapy.
TL;DR: An updated overview of glutamine metabolism and its involvement in tumorigenesis in vitro and in vivo is provided, and the recent potential applications of basic science discoveries in the clinical setting are explored.
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Emerging applications of metabolomics in drug discovery and precision medicine
TL;DR: This Review discusses some of the latest technological advances in metabolomics, focusing on the application of metabolomics towards uncovering the underlying causes of complex diseases, the growing role of metabolites in drug discovery and its potential effect on precision medicine.
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Cancer metabolism: fatty acid oxidation in the limelight
TL;DR: The important contribution of fatty acid oxidation to cancer cell function is brought to light in this Progress article.
References
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Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
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TOR signaling in growth and metabolism.
TL;DR: The physiological consequences of mammalianTORC1 dysregulation suggest that inhibitors of mammalian TOR may be useful in the treatment of cancer, cardiovascular disease, autoimmunity, and metabolic disorders.
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The metabolism of tumors in the body.
TL;DR: The question of whether tumor cells in living animals can be killed off through lack of energy, and the related question of how the tumors are supplied with oxygen and glucose in the body are discussed.
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Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes.
TL;DR: The embryo fibroblasts become tumorigenic if a second oncogene such as a viral or cellular myc gene or the gene for the polyoma large-T antigen is introduced together with the ras gene.