Glutathione Metabolism and Parkinson’s Disease
Reads0
Chats0
TLDR
The synthesis, metabolism, and functional interactions of glutathione are examined and how these relate to the protection of dopaminergic neurons from oxidative damage and its therapeutic potential in Parkinson disease are discussed.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2013-09-01 and is currently open access. It has received 359 citations till now. The article focuses on the topics: Oxidative stress & Glutathione.read more
Citations
More filters
Journal ArticleDOI
NADPH oxidases: an overview from structure to innate immunity-associated pathologies
TL;DR: A complete understanding of the function of NOX is important to direct the role of this enzyme towards host defense and tissue repair or increase resistance to stress in a timely and disease-specific manner.
Journal ArticleDOI
A novel and automated assay for thiol/disulphide homeostasis.
Ozcan Erel,Salim Neselioglu +1 more
TL;DR: In this paper, the authors developed a novel and automated assay determining plasma thiol/disulphide homeostasis, which consists of thiol-disoulphide exchanges.
Journal ArticleDOI
Antioxidants and human diseases
Peramaiyan Rajendran,Natarajan Nandakumar,Thamaraiselvan Rengarajan,Rajendran Palaniswami,Edwinoliver Nesamony Gnanadhas,Uppalapati Lakshminarasaiah,Jacob Gopas,Ikuo Nishigaki +7 more
TL;DR: The aim of this review is to highlight advances in understanding of the ROS and also to summarize the detailed impact and involvement of antioxidants in selected human diseases.
Journal ArticleDOI
Recent progress in development of siRNA delivery vehicles for cancer therapy
TL;DR: The current status of clinical trials related to siRNA-based cancer therapy is described, as well as the remaining issues that need to be overcome to establish a successful therapy, and various promising design strategies of delivery vehicles for stable and targeted siRNA delivery are introduced.
Journal ArticleDOI
Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease
TL;DR: It is argued that improving the ability to accurately measure oxidative stress, dopaminergic neurotransmission and cell death pathways in vivo is crucial for both the development of new therapies and the identification of novel disease biomarkers.
References
More filters
Journal ArticleDOI
Selenium: Biochemical Role as a Component of Glutathione Peroxidase
TL;DR: When hemolyzates from erythrocytes of selenium-deficient rats were incubated in vitro in the presence of ascorbate or H2O2, added glutathione failed to protect the hemoglobin from oxidative damage.
Journal ArticleDOI
Drug delivery and nanoparticles:applications and hazards
Wim H. de Jong,Paul J A Borm +1 more
TL;DR: An overview on some of the currently used systems for drug delivery, varying from biological substances like albumin, gelatine and phospholipids for liposomes, and more substances of a chemical nature like various polymers and solid metal containing nanoparticles is provided.
Journal ArticleDOI
Reactive Oxygen Species and the Central Nervous System
TL;DR: The nature of antioxidants is discussed, it being suggested that antioxidant enzymes and chelators of transition metal ions may be more generally useful protective agents than chain‐breaking antioxidants.
Journal ArticleDOI
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.
Masao Saitoh,Hideki Nishitoh,Makiko Fujii,Kohsuke Takeda,Kei Tobiume,Yasuhiro Sawada,Masahiro Kawabata,Kohei Miyazono,Hidenori Ichijo +8 more
TL;DR: Evidence that Trx is a negative regulator of ASK1 suggests possible mechanisms for redox regulation of the apoptosis signal transduction pathway as well as the effects of antioxidants against cytokine‐ and stress‐induced apoptosis.
Journal ArticleDOI
Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways
Hidenori Ichijo,Eisuke Nishida,Kenji Irie,Peter ten Dijke,Masao Saitoh,Tetsuo Moriguchi,Minoru Takagi,Kunihiro Matsumoto,Kohei Miyazono,Yukiko Gotoh +9 more
TL;DR: Overexpression of ASK1 induced apoptotic cell death, andASK1 was activated in cells treated with tumor necrosis factor-α, and TNF-α-induced apoptosis was inhibited by a catalytically inactive form of AsK1.