Journal ArticleDOI
Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines.
Céline Gasnier,Coralie Dumont,Nora Benachour,Emilie Clair,Marie-Christine Chagnon,Gilles-Eric Séralini +5 more
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TLDR
A real cell impact of glyphosate-based herbicides residues in food, feed or in the environment has thus to be considered, and their classifications as carcinogens/mutagens/reprotoxics is discussed.About:
This article is published in Toxicology.The article was published on 2009-08-21. It has received 535 citations till now. The article focuses on the topics: Genotoxicity & Endocrine disruptor.read more
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Hormones and endocrine-disrupting chemicals: Low-dose effects and nonmonotonic dose responses
Laura N. Vandenberg,Theo Colborn,Tyrone B. Hayes,Jerrold J. Heindel,David R. Jacobs,Duk Hee Lee,Toshi Shioda,Ana M. Soto,Wade V. Welshons,R. Thomas Zoeller,John Peterson Myers +10 more
TL;DR: It is concluded that when nonmonotonic dose-response curves occur, the effects of low doses cannot be predicted by the effects observed at high doses, and fundamental changes in chemical testing and safety determination are needed to protect human health.
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Trends in glyphosate herbicide use in the United States and globally
TL;DR: Glyphosate will likely remain the most widely applied pesticide worldwide for years to come, and interest will grow in quantifying ecological and human health impacts, according to published global pesticide use data.
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Chemical Pesticides and Human Health: The Urgent Need for a New Concept in Agriculture.
P. Nicolopoulou-Stamati,Sotirios Maipas,Chrysanthi Kotampasi,Panagiotis J. Stamatis,Luc Hens +4 more
TL;DR: It is more obvious than ever that the society needs the implementation of a new agricultural concept regarding food production, which is safer for man and the environment, and to this end, steps such as the declaration of Nyéléni have been taken.
Journal ArticleDOI
Concerns over use of glyphosate-based herbicides and risks associated with exposures: a consensus statement
John Peterson Myers,Michael Antoniou,Bruce Blumberg,Lynn Carroll,Theo Colborn,Lorne G. Everett,Michael Hansen,Philip J. Landrigan,Bruce P. Lanphear,Robin Mesnage,Laura N. Vandenberg,Frederick S. vom Saal,Wade V. Welshons,Charles Benbrook +13 more
TL;DR: GBHs are the most heavily applied herbicide in the world and usage continues to rise; Worldwide, GBHs often contaminate drinking water sources, precipitation, and air, especially in agricultural regions and regulatory estimates of tolerable daily intakes for glyphosate in the United States and European Union are based on outdated science.
Journal ArticleDOI
Potential toxic effects of glyphosate and its commercial formulations below regulatory limits.
TL;DR: A coherent body of evidence is revealed indicating that GlyBH could be toxic below the regulatory lowest observed adverse effect level for chronic toxic effects, which includes teratogenic, tumorigenic and hepatorenal effects.
References
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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
TL;DR: A tetrazolium salt has been used to develop a quantitative colorimetric assay for mammalian cell survival and proliferation and is used to measure proliferative lymphokines, mitogen stimulations and complement-mediated lysis.
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A simple technique for quantitation of low levels of DNA damage in individual cells
TL;DR: Human lymphocytes were exposed to X-irradiation or treated with H2O2 and the extent of DNA migration was measured using a single-cell microgel electrophoresis technique under alkaline conditions and this technique appears to be sensitive and useful for detecting damage and repair in single cells.
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Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability.
François Denizot,Rita Lang +1 more
TL;DR: The reliability and sensitivity of the test have been increased to the point where it can in many cases replace the [3H]thymidine uptake assay to measure cell proliferation or survival in growth factor or cytotoxicity assays.
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Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity
TL;DR: The identity of Alamar Blue is shown as resazurin, a very simple and versatile way of measuring cell proliferation and cytotoxicity that presents numerous advantages over other cytot toxicity or proliferation tests but there are several drawbacks to the routine use.