Journal ArticleDOI
Glyphosate induces human breast cancer cells growth via estrogen receptors
Siriporn Thongprakaisang,Apinya Thiantanawat,Apinya Thiantanawat,Nuchanart Rangkadilok,Nuchanart Rangkadilok,Tawit Suriyo,Jutamaad Satayavivad,Jutamaad Satayavivad,Jutamaad Satayavivad +8 more
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TLDR
The results indicated that low and environmentally relevant concentrations of glyphosate possessed estrogenic activity and there was an additive estrogenic effect between glyphosate and genistein, a phytoestrogen in soybeans, however, these additive effects of glyphosate contamination in soybean cultivation need further animal study.About:
This article is published in Food and Chemical Toxicology.The article was published on 2013-09-01. It has received 329 citations till now. The article focuses on the topics: Estrogen receptor & Genistein.read more
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Trends in glyphosate herbicide use in the United States and globally
TL;DR: Glyphosate will likely remain the most widely applied pesticide worldwide for years to come, and interest will grow in quantifying ecological and human health impacts, according to published global pesticide use data.
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Chemical Pesticides and Human Health: The Urgent Need for a New Concept in Agriculture.
P. Nicolopoulou-Stamati,Sotirios Maipas,Chrysanthi Kotampasi,Panagiotis J. Stamatis,Luc Hens +4 more
TL;DR: It is more obvious than ever that the society needs the implementation of a new agricultural concept regarding food production, which is safer for man and the environment, and to this end, steps such as the declaration of Nyéléni have been taken.
Journal ArticleDOI
Concerns over use of glyphosate-based herbicides and risks associated with exposures: a consensus statement
John Peterson Myers,Michael Antoniou,Bruce Blumberg,Lynn Carroll,Theo Colborn,Lorne G. Everett,Michael Hansen,Philip J. Landrigan,Bruce P. Lanphear,Robin Mesnage,Laura N. Vandenberg,Frederick S. vom Saal,Wade V. Welshons,Charles Benbrook +13 more
TL;DR: GBHs are the most heavily applied herbicide in the world and usage continues to rise; Worldwide, GBHs often contaminate drinking water sources, precipitation, and air, especially in agricultural regions and regulatory estimates of tolerable daily intakes for glyphosate in the United States and European Union are based on outdated science.
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Potential toxic effects of glyphosate and its commercial formulations below regulatory limits.
TL;DR: A coherent body of evidence is revealed indicating that GlyBH could be toxic below the regulatory lowest observed adverse effect level for chronic toxic effects, which includes teratogenic, tumorigenic and hepatorenal effects.
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Hazardous effects of chemical pesticides on human health-Cancer and other associated disorders.
TL;DR: The most common diseases including cancer which are associated with pesticides are reviewed and many pesticides have shown to be involved in the pathogenesis of Parkinson's and Alzheimer's diseases as well as various disorders of the respiratory and reproductive tracts.
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Journal ArticleDOI
Dietary Isoflavones: Biological Effects and Relevance to Human Health
TL;DR: This review focuses on the more recent studies pertinent to this field and includes, where appropriate, the landmark and historical literature that has led to the exponential increase in interest in phytoestrogens from a clinical nutrition perspective.
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Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines.
Céline Gasnier,Coralie Dumont,Nora Benachour,Emilie Clair,Marie-Christine Chagnon,Gilles-Eric Séralini +5 more
TL;DR: A real cell impact of glyphosate-based herbicides residues in food, feed or in the environment has thus to be considered, and their classifications as carcinogens/mutagens/reprotoxics is discussed.
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Differential effects of glyphosate and roundup on human placental cells and aromatase.
TL;DR: It is shown that glyphosate is toxic to human placental JEG3 cells within 18 hr with concentrations lower than those found with agricultural use, and this effect increases with concentration and time, and the presence of Roundup adjuvants enhances glyphosate bioavailability and/or bioaccumulation.
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Molecular effects of genistein on estrogen receptor mediated pathways
TL;DR: Genistein, though estrogenic, can interfere with the effects of estradiol and prolonged exposure to genistein resulted in a decrease in estrogen receptor mRNA level as well as a decreased response to stimulation byEstradiol.