Green synthesis of gold nanoparticles with Zingiber officinale extract: Characterization and blood compatibility
TL;DR: The usage of nanoparticles, synthesized with Z. officinale extract, as vectors for the applications in drug delivery, gene delivery or as biosensors, where a direct contact with blood occurs is justified.
About: This article is published in Process Biochemistry.The article was published on 2011-10-01. It has received 274 citations till now. The article focuses on the topics: Colloidal gold & Low protein.
Citations
More filters
TL;DR: In this article, general principles and recent developments in the synthesis of gold nanoparticles (AuNPs) are reviewed and a review of seed-growth methods have allowed a precise control of AuNP sizes in a broad range and multiple shapes.
758 citations
TL;DR: This critical review will discuss the various clinical applications of gold, silver and platinum nanoparticles with relevance to above parameters and mention various routes of synthesis of these noble metal nanoparticles.
Abstract: Biomedical nanotechnology is an evolving field having enormous potential to positively impact the health care system. Important biomedical applications of nanotechnology that may have potential clinical applications include targeted drug delivery, detection/diagnosis and imaging. Basic understanding of how nanomaterials, the building blocks of nanotechnology, interact with the cells and their biological consequences are beginning to evolve. Noble metal nanoparticles such as gold, silver and platinum are particularly interesting due to their size and shape dependent unique optoelectronic properties. These noble metal nanoparticles, particularly of gold, have elicited a lot of interest for important biomedical applications because of their ease of synthesis, characterization and surface functionalization. Furthermore, recent investigations are demonstrating another promising application of these nanomaterials as self-therapeutics. To realize the potential promise of these unique inorganic nanomaterials for future clinical translation, it is of utmost importance to understand a few critical parameters; (i) how these nanomaterials interact with the cells at the molecular level; (ii) how their biodistribution and pharmacokinetics influenced by their surface and routes of administration; (iii) mechanism of their detoxification and clearance and (iv) their therapeutic efficacy in appropriate disease model. Thus in this critical review, we will discuss the various clinical applications of gold, silver and platinum nanoparticles with relevance to above parameters. We will also mention various routes of synthesis of these noble metal nanoparticles. However, before we discuss present research, we will also look into the past. We need to understand the discoveries made before us in order to further our knowledge and technological development (318 references).
666 citations
TL;DR: The present review targets the comparative biogenic synthesis and mechanisms of nanoparticles using algae and waste materials (agro waste in the presence of biomolecules) and some of the applications of the biosynthesized nanoparticles in biomedical, catalysis and biosensors fields.
522 citations
TL;DR: In this article, a green approach for the synthesis and stabilization of silver nanoparticles (AgNPs) using water extract of Terminalia chebula fruit under ambient conditions is reported, where instant formation of AgNPs was analyzed by visual observation and UV-visible spectrophotometer.
399 citations
TL;DR: The key applications reviewed here include biomedical applications, especially antimicrobial applications, but also imaging applications, catalytic applications such as reduction of environmental contaminants, and electrochemical applications including sensing.
363 citations
Cites background from "Green synthesis of gold nanoparticl..."
...[20] described the blood compatibility of AuNPs synthesized with ginger (Zingiber officionale) extract....
[...]
...One approach to avoiding toxicity concerns is to use only well-characterized and benign botanical extracts for biosynthesis [20]....
[...]
References
More filters
Book•
01 Jan 1983
TL;DR: In this paper, a Potpourri of Particles is used to describe surface modes in small Particles and the Angular Dependence of Scattering is shown to be a function of the size of the particles.
Abstract: BASIC THEORY. Electromagnetic Theory. Absorption and Scattering by an Arbitrary Particle. Absorption and Scattering by a Sphere. Particles Small Compared with the Wavelength. Rayleigh--Gans Theory. Geometrical Optics. A Potpourri of Particles. OPTICAL PROPERTIES OF BULK MATTER. Classical Theories of Optical Constants. Measured Optical Properties. OPTICAL PROPERTIES OF PARTICLES. Extinction. Surface Modes in Small Particles. Angular Dependence of Scattering. A Miscellany of Applications. Appendices. References. Index.
16,859 citations
TL;DR: In this paper, the use of optical measurements to monitor electrochemical changes on the surface of nanosized metal particles is discussed within the Drude model, and the absorption spectrum of a metal sol in water is shown to be strongly affected by cathodic or anodic polarization, chemisorption, metal adatom deposition, and alloying.
Abstract: The use of optical measurements to monitor electrochemical changes on the surface of nanosized metal particles is discussed within the Drude model. The absorption spectrum of a metal sol in water is shown to be strongly affected by cathodic or anodic polarization, chemisorption, metal adatom deposition, and alloying. Anion adsorption leads to strong damping of the free electron absorption. Cathodic polarization leads to anion desorption. Underpotential deposition (upd) of electropositive metal layers results in dramatic blue-shifts of the surface plasmon band of the substrate. The deposition of just 0.1 monolayer can be readily detected by eye. In some cases alloying occurs spontaneously during upd. Alloy formation can be ascertained from the optical absorption spectrum in the case of gold deposition onto silver sols. The underpotential deposition of silver adatoms onto palladium leads to the formation of a homogeneous silver shell, but the mean free path is less than predicted, due to lattice strain in t...
3,454 citations
TL;DR: Gold nanoparticles provide non-toxic carriers for drug and gene delivery applications and their interaction with thiols is an effective and selective means of controlled intracellular release.
2,383 citations
"Green synthesis of gold nanoparticl..." refers background in this paper
...Metal and semiconducor nanoparticles are very important due to their unusual size and hape dependant properties [1] and are found to have potential pplications in biological and chemical sensing of single molecules 2], controlled release of biologically relevant molecules [3], catalsis [4] and immunoassays [5]....
[...]
TL;DR: The rates of reduction of the metal ions by Neem leaf extract are much faster than those observed by us in earlier studies using microorganisms such as fungi, highlighting the possibility that nanoparticle biological synthesis methodologies will achieve rates of synthesis comparable to those of chemical methods.
2,339 citations
TL;DR: This Review highlights recent advances in the synthesis, bioconjugation, and cellular uses of gold nanoconjugates.
Abstract: Gold colloids have fascinated scientists for over a century and are now heavily utilized in chemistry, biology, engineering, and medicine. Today these materials can be synthesized reproducibly, modified with seemingly limitless chemical functional groups, and, in certain cases, characterized with atomic-level precision. This Review highlights recent advances in the synthesis, bioconjugation, and cellular uses of gold nanoconjugates. There are now many examples of highly sensitive and selective assays based upon gold nanoconjugates. In recent years, focus has turned to therapeutic possibilities for such materials. Structures which behave as gene-regulating agents, drug carriers, imaging agents, and photoresponsive therapeutics have been developed and studied in the context of cells and many debilitating diseases. These structures are not simply chosen as alternatives to molecule-based systems, but rather for their new physical and chemical properties, which confer substantive advantages in cellular and medical applications.
2,063 citations