Journal ArticleDOI
Green tea polyphenol epigallocatechin-3-gallate protects HepG2 cells against CYP2E1-dependent toxicity
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TLDR
Green tea flavanol epigallocatechin-3-gallate exerts a protective action on CYP2E1-dependent oxidative stress and toxicity that may contribute to preventing alcohol-induced liver injury, and may be useful in preventing toxicity by various hepatotoxins activated by CYP 2E1 to reactive intermediates.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2004-02-01. It has received 55 citations till now. The article focuses on the topics: Oxidative stress & Lipid peroxidation.read more
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Journal ArticleDOI
New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate.
TL;DR: Green tea is rich in polyphenol flavonoids including catechins, and EGCG directly interacts with proteins and phospholipids in the plasma membrane and regulates signal transduction pathways, transcription factors, DNA methylation, mitochondrial function, and autophagy to exert many of its beneficial biological actions.
Journal ArticleDOI
Oxidative stress is bane in chronic liver diseases: Clinical and experimental perspective.
TL;DR: This review summarizes the relationships between oxidative stress and different liver pathogenesis induced by drugs and xenobiotics, focusing upon different chronic liver injury induced by alcohol, antitubercular drugs and hyperactivity of antiretroviral drugs in HIV patients, viral hepatitis infection induced oxidative stress.
Journal ArticleDOI
Biological functionality of ellagic acid: a review
D.A. Vattem,Kalidas Shetty +1 more
TL;DR: A comprehensive model for the antioxidant response-linked mechanism of the action of ellagic acid from fruits at the early stages of host cellular response by the modulation of enzyme response to maintain cellular homeostasis in eukaryotes and by inhibiting the survival in pathogenic prokaryotes is proposed.
Journal ArticleDOI
Tea Polyphenols Decrease Serum Levels of Prostate-Specific Antigen, Hepatocyte Growth Factor, and Vascular Endothelial Growth Factor in Prostate Cancer Patients and Inhibit Production of Hepatocyte Growth Factor and Vascular Endothelial Growth Factor In vitro
Jerry McLarty,Rebecca L. H. Bigelow,Mylinh Smith,Don Elmajian,Murali Ankem,James A. Cardelli +5 more
TL;DR: Results show a significant reduction in serum levels of PSA, HGF, and VEGF in men with prostate cancer after brief treatment with EGCG (Polyphenon E), with no elevation of liver enzymes, which support a potential role for PolyphenonE in the treatment or prevention of prostate cancer.
Journal ArticleDOI
The effects of bioactive compounds from plant foods on mitochondrial function: a focus on apoptotic mechanisms.
Tamara Y. Forbes-Hernandez,Francesca Giampieri,Massimiliano Gasparrini,Luca Mazzoni,José L. Quiles,José M. Alvarez-Suarez,Maurizio Battino +6 more
TL;DR: This review summarizes and updates the most recent findings concerning the mechanisms through which different dietary compounds from plant foods affect mitochondria functionality in healthy and pathological in vitro and in vivo models, paying particular attention to the pathways involved in mitochondrial biogenesis and apoptosis.
References
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Journal ArticleDOI
Free Radicals in the Physiological Control of Cell Function
TL;DR: There is growing evidence that aging involves, in addition, progressive changes in free radical-mediated regulatory processes that result in altered gene expression.
Journal ArticleDOI
Structure-antioxidant activity relationships of flavonoids and phenolic acids
TL;DR: The factors underlying the influence of the different classes of polyphenols in enhancing their resistance to oxidation are discussed and support the contention that the partition coefficients of the flavonoids as well as their rates of reaction with the relevant radicals define the antioxidant activities in the lipophilic phase.
Journal ArticleDOI
Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues
TL;DR: The use of the foregoing analytical method in the determination of total and oxidized glutathione contents of rat blood, kidney, and liver gave values in good agreement with those obtained by previous investigators.
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Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study.
TL;DR: Flavonoids in regularly consumed foods may reduce the risk of death from coronary heart disease in elderly men and showed an inverse relation with incidence of myocardial infarction.
Book ChapterDOI
Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal
TL;DR: This chapter discusses the methods used for the qualitative and quantitative determination of aldehydes in biological systems and focuses on 4-hydroxynonenal and malondialdehyde, which are in many instances the most abundant individual aldehyde resulting from lipid peroxidation.