Groundnut oil based emulsion gels for passive and iontophoretic delivery of therapeutics
Vinay Singh,Indu Yadav,Senthilguru Kulanthaivel,Bibhas Roy,Supratim Giri,Tapas K. Maiti,Indranil Banerjee,Kunal Pal +7 more
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TLDR
Groundnut oil-based emulsion gels can be an efficient and stable multimodal carrier system for the passive and the active delivery of both hydrophilic and lipophilic drugs.Abstract:
There is a persistent demand for an efficient drug delivery system, suitable for the delivery of both hydrophilic and lipophilic drugs. This study explores groundnut oil-based emulsion gels for the above-mentioned application. On the basis of stability, two representative gels OG5-80 (low oil content) and OG7-45 (high oil content) were studied further. Analysis of microarchitecture by ESEM and confocal microscopy, in conjugation with fluorescence recovery after photobleaching, confirmed the conversion of the dispersion phase from oil-continuous (OG7-45) to bicontinuous (OG5-80) with increasing water proportion. The gels were viscoelastic with unique stress relaxation properties. Passive and active (iontophoretic) release kinetics of the drugs showed differential release patterns. Mathematical modeling elucidated composition-dependent temporal variation in the drug release and stress relaxation patterns. In vitro cell viability study, cell cycle analysis, and immunocytochemistry divulged compatibil...read more
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Release of small bioactive molecules from physical gels.
TL;DR: This review summarizes the use of physical (or supramolecular) gels derived from low molecular weight compounds for the encapsulation and controlled release of small therapeutic molecules.
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Magnetic nanoparticle incorporated oleogel as iontophoretic drug delivery system.
Soumyashree Dhal,Abhinav Mohanty,Indu Yadav,K. Uvanesh,Senthilguru Kulanthaivel,Indranil Banerjee,Kunal Pal,Supratim Giri +7 more
TL;DR: The use of electric current as an external stimulus to induce an enhancement of drug release from magnetic nanoparticle (MNP) incorporated organogels (magnetogel) under iontophoretic conditions is validated.
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Magnetic nanoparticle incorporated oleogel as iontophoretic drug delivery system B Biointerfaces
Soumyashree Dhal,Abhinav Mohanty,Indu Yadav,K. Uvanesh,Senthilguru Kulanthaivel,Indranil Banerjee,Kunal Pal,Supratim Giri +7 more
TL;DR: In this article, the authors used electric current as an external stimulus to induce an enhancement of drug release from magnetic nanoparticles (MNP) incorporated organogels (magnetogel) under iontophoretic conditions.
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Fluorescence Recovery after Photobleaching in Colloidal Science: Introduction and Application.
TL;DR: A review of the existing research on employing FRAP to measure colloidal system heterogeneity and explore diffusion into complicated structures can be found in this article , where a detailed description of FRAP is given.
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Graphene oxide reinforced nanocomposite oleogels improves corneal permeation of drugs
Anand Mohan Hasda,Shanmuga Sharan Rathnam Vuppaladadium,Dilshad Qureshi,Girija Prasad,Biswaranjan Mohanty,Indranil Banerjee,Hamid Shaikh,Arfat Anis,Preetam Sarkar,Kunal Pal +9 more
TL;DR: In this paper, a series of novel nanocomposite oleogels of groundnut oil (GNO) and stearic acid (SA) were prepared, which contained graphene oxide (GO) in the concentration range of 0.00 to 0.05% of GO.
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